Results 151 to 160 of about 1,156,952 (310)

Integrated Numerical Modelling System for Extreme Wave Events at the Wave Hub Site [PDF]

, 2013
This paper examines an extreme wave event which occurred during a storm at the Wave Hub site in 2012. The extreme wave of 9.57 m height was identified from a time series of the heave data collected by an Oceanor Seawatch Mini II Buoy deployed at the site.
Conley, D, Greaves, D, Hann, M, Magagna, D, Magar, V, Ransley, EJ, Simmonds, D, Vyzikas, T   +7 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Five years of high-frequency data of phytoplankton zooplankton and limnology from a temperate eutrophic lake

Scientific Data
This study presents a comprehensive dataset from Lake Greifen, Switzerland, collected between April 2018 and June 2023, using high-frequency automated monitoring systems.
Stefanie Eyring, Marta Reyes, Ewa Merz, Marco Baity-Jesi, Pinelopi Ntetsika, Christian Ebi, Stuart Dennis, Francesco Pomati   +7 more
doaj   +1 more source

Integrated Modelling of European Migration: Background, specification and results [PDF]

The aims of this paper are to present the background and specification of the Integrated Modelling of European Migration (IMEM) model. Currently, international migration data are collected by individual countries with separate collection systems and ...
Arkadiusz Wiśniowski, Jakub Bijak, James Raymer, Jonathan J. Forster, Peter W.F Smith   +4 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Models for model integration

, 2017
This is a presentation given at the Crops in silico 2nd Annual Symposium and Workshop, Oxford, UK, 27 June 2017. It covers some ideas about different types of models and how they can be put together using frameworks, as well as how one specific tool, the Parsl python parallel scripting library, can be used to assemble and execute loosely-coupled ...
openaire   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source