Results 31 to 40 of about 25,043 (261)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Energy efficient photonic memory based on electrically programmable embedded III-V/Si memristors: switches and filters

Communications Engineering
Over the past few years, extensive work on optical neural networks has been investigated in hopes of achieving orders of magnitude improvement in energy efficiency and compute density via all-optical matrix-vector multiplication. However, these solutions
Stanley Cheung, Bassem Tossoun, Yuan Yuan, Yiwei Peng, Yingtao Hu, Wayne V. Sorin, Geza Kurczveil, Di Liang, Raymond G. Beausoleil   +8 more
doaj   +1 more source

Hybrid and heterogeneous photonic integration

APL Photonics, 2021
Increasing demand for every faster information throughput is driving the emergence of integrated photonic technology. The traditional silicon platform used for integrated electronics cannot provide all of the functionality required for fully integrated ...
Paramjeet Kaur, Andreas Boes, Guanghui Ren, Thach G. Nguyen, Gunther Roelkens, Arnan Mitchell   +5 more
doaj   +1 more source

Spatially Resolved Protein Binding Kinetics Analysis in Microfluidic Photonic Crystal Sensors

Sensors, 2023
Organ-on-a-Chip systems are emerging as an important in vitro analysis method for drug screening and medical research. For continuous biomolecular monitoring of the cell culture response, label-free detection within the microfluidic system or in the ...
Stefanie Lehmann, Fabio Aldo Kraft, Martina Gerken   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Emission Rate Variation and Efficiency Measurement in TiO2 Light Emitting Diode

MATEC Web of Conferences, 2016
Titanium dioxide light emitting diode was successfully designed and characterised. An approach in developing TiO2 was based on cylindrically symmetric configuration with shorter computation time.
Ariffin S.N., Hambali N.A.M.A., Wahid M.H.A., Shahimin M.M., Sahbudin U.K., Saidi N.N.A.   +5 more
doaj   +1 more source

Silicon photonics-integrated time-domain balanced homodyne detector for quantum tomography and quantum key distribution

New Journal of Physics, 2023
We designed and experimentally demonstrated a silicon photonics-integrated time-domain balanced homodyne detector (TBHD), containing an optical part of dimensions of 1.5 mm × 0.4 mm.
Yanxiang Jia, Xuyang Wang, Xiao Hu, Xin Hua, Yu Zhang, Xubo Guo, Shengxiang Zhang, Xi Xiao, Shaohua Yu, Jun Zou, Yongmin Li   +10 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

NOVEL PRINCIPLES OF MICROWAVE BAND RADIOELECTRONIC DEVICES DESIGN WITH THE USE OF MICROWAVE PHOTONICS TECHNOLOGY

Российский технологический журнал, 2016
There are highlighted fundamental and practical advantages referred to introduction of the new interdisciplinary scientific and technological direction, that is, microwave photonics, in modern and perspective radio means of a dual purpose.
M. E. Belkin, S. A. Kudzh, A. S. Sigov
doaj   +1 more source

Monolithic Integrated OLED–OPD Unit for Point-of-Need Nitrite Sensing

Sensors, 2022
In this study, we present a highly integrated design of organic optoelectronic devices for Point-of-Need (PON) nitrite (NO2−) measurement. The spectrophotometric investigation of nitrite concentration was performed utilizing the popular Griess reagent ...
Igor Titov, Markus Köpke, Martina Gerken   +2 more
doaj   +1 more source