Results 71 to 80 of about 4,195,537 (293)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Community Colleges: The Next Frontier of Recovery Support at Institutions of Higher Education [PDF]

open access: yes, 2018
In 2016, TYR could identify only six community colleges offering recovery support programs and services. Based on this finding, TYR identified a need for pilot programs to better understand programmatic models that may be effective for supporting ...
Jones, Erin K
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Water Recovery from Laundry Wastewater by Integrated Purification Systems

open access: yesMembranes
Integrated systems for water recovery from laundry wastewater were investigated to close the water cycle loop. The grey water from the washing cycle of cotton fabrics with a softening detergent was prefiltered, purified in a low-pressure membrane process,
Aleksandra Klimonda, Izabela Kowalska
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Applied Analysis on Electromagnetic Braking in the Vehicle Braking Energy Recovery

open access: yesJixie chuandong, 2016
The working principle and characteristic of the braking energy recovery system are introduced.The working principle of automotive electromagnetic braking is introduced.
Tu Kun, He Ren
doaj  

Reframing disaster recovery through spatial justice: an integrated framework

open access: yesBuildings & Cities
Post-disaster recovery is widely regarded as the least understood, yet highly consequential, phase of disaster management, shaping both short consequences and long-term trajectories of affected communities.
Mehmet Ali Gasseloğlu   +1 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

The Impact of Temperature and Ethanol Concentration on the Global Recovery of Specific Polyphenols in an Integrated HPLE/RP Process on Carménère Pomace Extracts

open access: yesMolecules, 2019
Sequential extraction and purification stages are required to obtain extracts rich in specific polyphenols. However, both separation processes are often optimized independently and the effect of the integrated process on the global recovery of ...
Nils Leander Huaman-Castilla   +5 more
doaj   +1 more source

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