Results 81 to 90 of about 1,281,413 (300)

Analytical simulation of the Langley Research Center integrated life-support system, volume 1 [PDF]

open access: yes
Analytical simulation of integrated life support system and oxygen recovery ...
Barker, R. S., Taylor, B. N.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Dynamic modelling of meat plant energy systems : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology at Massey University [PDF]

open access: yes, 1993
The objective of this study was to develop dynamic mathematical models of the major energy use and recovery operations within the New Zealand meat industry.
Kallu, Rodger David Stephen
core  

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Metacognitive reflection and insight therapy: a mini-review of advances, challenges, and future directions

open access: yesFrontiers in Psychology
Metacognitive Reflection and Insight Therapy (MERIT) is a significant development in psychotherapy for schizophrenia spectrum disorders, emphasizing meaning-making, self-understanding, and self-directed recovery.
Courtney N. Wiesepape   +5 more
doaj   +1 more source

Red-Cockaded Woodpecker Recovery: An Integrated Strategy [PDF]

open access: yes, 2004
Populations of the red-cockaded woodpecker (Picoides borealis) have experienced massive declines since European colonization of North America. This is due to extensive habitat loss and alteration.
Conner, Richard N.   +2 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Feasibility and performance efficiency of integrated microbial nutrient recovery cell and microalgae-activated sludge process for wastewater treatment

open access: yesWaste Management Bulletin
Microbial nutrient recovery cell (MNRC) and microalgae-activated sludge (MAAS) are both the most attractive emerging methods of wastewater treatment technology due to their promising potential to revolutionize wastewater treatment systems.
Samson Balogun   +3 more
doaj   +1 more source

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