Results 101 to 110 of about 298,694 (309)
Application of “one network one station” wireless communication system in coal mine
Gong-kuang zidonghua, 2015 For problems of disperse management and difficult maintenance of each informatization system in Shendong Coal Mine, as well as difficult recovering and inconvenient emergency rescue after accidents, a “one network one station” wireless communication ...
WANG Haijun, REN Ze
doaj +1 more source
Dangerous calling, the life-and-death matter of safety at sea: a collection of articles from SAMUDRA Report [PDF]
, 2003 Fishing is arguably the world's most dangerous vocation, reporting the highest rate of occupational fatalities among industries, made only worse by declining fish prices, overfished waters and shortened fishing seasons.
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Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles. [PDF]
, 2018 Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those ...
Arizala, Jerlisa Ann C +5 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Construction of karst cave rescue system: A case study of Guizhou Province
Carsologica SinicaSince the 1980s, with the development of joint spelunking activities between China and other countries, modern spelunking activities and techniques have been introduced and gradually promoted in China. Spelunking is now emerging as a popularized activity,
Shuwen LUO +14 more
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Научный вестник МГТУ ГА, 2018 The article considers the software of optimization technology allowing to enhance the work of the aerospace search and rescue system in terms of making decisions on the use of aircraft.
A. V. Sobolev, V. A. Popov
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Operation Modulus: Putting Christie into Practice in Gorbals [PDF]
, 2016 As part of its exploration of public service reform What Works Scotland carried out an evaluation of Operation Modulus, a highly successful, innovative, award winning violence and anti-social behaviour intervention targeted at a gang of young people in
Brunner, Richard, Watson, Nick
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source