Results 101 to 110 of about 300,999 (301)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Energy Science & EngineeringMountain climbing often involves sudden weather changes, group separation, and mobile device battery depletion, which can lead to life‐threatening emergencies.
Jian‐Sheng Huang, Li‐Chin Shih
doaj +1 more source
A modular casing while drilling rig for large-diameter horizontal boreholes for underground rescue
Meitian dizhi yu kantanObjectiveOperations in a narrow space pose a challenge to rescue in the case of the collapse of mine roadways or tunnels. To address this challenge, this study developed a modular rescue casing while drilling (CwD) rig system for horizontal boreholes ...
Dong FAN +6 more
doaj +1 more source
Labour Administration Reforms in China [PDF]
, 2013 [Excerpt] This publication provides an explanation of the comprehensive labour administration system in China, including its recent advances, with emphasis on its public services functions, such as public employment, labour inspection and social ...
Casale, Giuseppe, Zhu, Changyou
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Application of “one network one station” wireless communication system in coal mine
Gong-kuang zidonghua, 2015 For problems of disperse management and difficult maintenance of each informatization system in Shendong Coal Mine, as well as difficult recovering and inconvenient emergency rescue after accidents, a “one network one station” wireless communication ...
WANG Haijun, REN Ze
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Construction of karst cave rescue system: A case study of Guizhou Province
Carsologica SinicaSince the 1980s, with the development of joint spelunking activities between China and other countries, modern spelunking activities and techniques have been introduced and gradually promoted in China. Spelunking is now emerging as a popularized activity,
Shuwen LUO +14 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source