Results 131 to 140 of about 63,403 (312)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A solution approach for dynamic vehicle and crew scheduling

In this paper, we discuss the dynamic vehicle and crew schedulingproblem and we propose a solution approach consisting of solving asequence of optimization problems.
Wagelmans, A.P.M., Huisman, D.
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

What Is the Optimal Solution for Scheduling Multiple Energy Systems? Overview and Analysis of Integrated Energy Co-Dispatch Models

Energies
With increasing dual pressure from global large energy consumption and environmental protection, multiple integrated energy systems (IESs) can provide more effective ways to achieve better energy utilization performance. However, in actual circumstances,
Xiaozhi Gao, Han Xiao, Shiwei Xu, Hsiung-Cheng Lin, Pengyu Chang   +4 more
doaj   +1 more source

Proactive-reactive procedures for robust project scheduling. [PDF]

The vast majority of research efforts in project scheduling concentrates on developing procedures to generate workable baseline schedules that minimize the project makespan in a deterministic environment.
Van de Vonder, Stijn
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Aggregated regulation and coordinated scheduling of PV-storage integrated 5G base stations considering PV-load uncertainty

International Journal of Electrical Power & Energy Systems
Photovoltaic (PV)-storage integrated 5G base station (BS) can participate in demand response on a large scale, conduct electricity transaction and provide auxiliary services, thus reducing the high electricity consumption of 5G BSs and increasing the ...
Congfei Li, Jiayi Liu, Tian Ding, Xi Liu, Zhenyu Zhou, Zhongwei Sun   +5 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Application of genetic algorithms for irrigation water scheduling

, 2009
A typical irrigation scheduling problem is one of preparing a schedule to service a group of outlets. These outlets may either be serviced sequentially or simultaneously.
Haq, Zia Ul
core  

A Case Study of Scheduling Storage Tanks Using a Hybrid Genetic Algorithm

, 2001
YesThis paper proposes the application of a hybrid genetic algorithm (GA) for scheduling storage tanks. The proposed approach integrates GAs and heuristic rule-based techniques, decomposing the complex mixed-integer optimization problem into integer and ...
Dahal, Keshav P., Burt, G.M., Dahal, K., Moyes, A., Moyes, A.J., McDonald, J.R.   +5 more
core   +1 more source