Results 141 to 150 of about 63,403 (312)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Low-carbon economic dispatching of integrated energy system based on improved white shark algorithm
Diance yu yibiaoAiming at the problem of low-carbon economic dispatching of integrated energy system, this paper considers the synergistic effect of carbon tax and carbon emission economic cost, and establishes a negative impact model of carbon tax on carbon emissions ...
LI Haobo, CUI Shuangxi, FAN Weijie
doaj +1 more source
Project scheduling under undertainty – survey and research potentials. [PDF]
The vast majority of the research efforts in project scheduling assume complete information about the scheduling problem to be solved and a static deterministic environment within which the pre-computed baseline schedule will be executed. However, in the
Herroelen, Willy, Leus, Roel
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Crew Scheduling for Netherlands Railways: "destination: customer"
: In this paper we describe the use of a set covering model with additional constraints for scheduling train drivers and conductors for the Dutch railway operator NS Reizigers.
Fischetti, M., Kroon, L.G.
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An Integrated Approach to Ex-Urban Crew and Vehicle Scheduling
, 1999 Vehicle scheduling and crew scheduling are the two major steps in public mass transit management. Their integration provides great opportunities for improving efficiency, but the size of the integrated problem poses a challenge.
Maddalena Nonato +3 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Integrated Control and Real-Time Scheduling. [PDF]
, 2003 The topic of the thesis is codesign of flexible real-time control systems. Integrating control theory and real-time scheduling theory, it is possible to achieve higher resource utilization and better control performance. The integration requires new tools for analysis, design, and implementation.
openaire +1 more source
Proactive resource allocation heuristics for robust project scheduling. [PDF]
The well-known deterministic resource-constrained project scheduling problem (RCPSP) involves the determination of a predictive schedule (baseline schedule or pre-schedule) of the project activities that satisfies the finish-start precedence relations ...
Braeckmans, Kristof +3 more
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