Results 81 to 90 of about 44,724 (245)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A dynamic integrated scheduling method based on hierarchical planning for heterogeneous AGV fleets in warehouses. [PDF]

Front Neurorobot, 2022
Hu E, He J, Shen S.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Integrated scheduling of distributed production and distribution in group manufacturing with uncertain travel time. [PDF]

Complex Intell Systems, 2023
Guo J, Liu W, Peng Z, Du B.
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A Two-Workshop Collaborative, Integrated Scheduling Algorithm considering the Prescheduling of the Root-Subtree Processes. [PDF]

Comput Intell Neurosci, 2022
Xie Z, Teng H, Ming J, Yue X.
europepmc   +1 more source

Integrated Workshop Schedule [PDF]

2021 International Conference on Computer Communications and Networks (ICCCN), 2021
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Collaborative Optimization of Oil Blending and Distribution in Refinery Based on Variable-driven Method

Journal of Chemical Engineering of Japan
Collaborative optimization has received much attention from both research and industry communities for its significant profits. However, the current researches primarily concentrate on optimizing individual subprocesses of refinery operations.
Yuandong Chen, Zihan Lin, Jinhao Pang, Yuchen Gou, Shaofeng Zheng, Dewang Chen   +5 more
doaj   +1 more source

Modelling of integrated scheduling problem of capacitated equipment systems with a multi-lane road network. [PDF]

PLoS One, 2021
Luan D, Zhao M, Zhao Q, Wang N.
europepmc   +1 more source