Results 91 to 100 of about 619,194 (267)

Integrated analysis of socioeconomic inequalities in contaminated sites: a case study

Rivista Italiana di Economia Demografia e Statistica
The study presents a prototype framework for integrated analysis aimed at assessing socioeconomic and demographic profiles in Sites of National Interest (SIN), applied to the Sulcis-Iglesiente-Guspinese SIN site (in south-western Sardinia). The developed model combines demographic, economic, educational attainment, employment data and is structured on ...
Daniela Vacca, Francesca Abate, Adriano Cabras, Enrico Olla, Giovanna Pala, Stefano Tersigni, Luigi Minerba   +6 more
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Exploring the Feasibility of Service Integration in a Low-Income Setting: A Mixed Methods Investigation into Different Models of Reproductive Health and HIV Care in Swaziland.

PLoS ONE, 2015
Integrating reproductive health (RH) with HIV care is a policy priority in high HIV prevalence settings, despite doubts surrounding its feasibility and varying evidence of effects on health outcomes.
Kathryn Church, Alison Wringe, Simon Lewin, George B Ploubidis, Phelele Fakudze, Integra Initiative, Susannah H Mayhew   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A comprehensive GIS-driven multi-criteria framework for offshore floating hybrid wind-solar site selection and performance analysis

International Journal of Thermofluids
The increasing global demand for sustainable energy has prompted the exploration of hybrid renewable systems, particularly in offshore environments. This study presents an integrated, Geographic Information System (GIS)-enabled multi-criteria decision ...
Bhasuru Abhinaya Srinivas, Manthan Shah, Shreekant Varshney   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Implementing a pharmacist-integrated collaborative model of medication treatment for opioid use disorder in primary care: study design and methodological considerations

Addiction Science & Clinical Practice
Background Pharmacists remain an underutilized resource in the treatment of opioid use disorder (OUD). Although studies have engaged pharmacists in dispensing medications for OUD (MOUD), few studies have evaluated collaborative care models in which ...
Bethany McLeman, Phoebe Gauthier, Laurie S. Lester, Felicity Homsted, Vernon Gardner, Sarah K. Moore, Paul J. Joudrey, Lisa Saldana, Gerald Cochran, Jacklyn P. Harris, Kathryn Hefner, Edward Chongsi, Kimberly Kramer, Ashley Vena, Rebecca A. Ottesen, Tess Gallant, Jesse S. Boggis, Deepika Rao, Marjorie Page, Nicholas Cox, Michelle Iandiorio, Ekow Ambaah, Udi Ghitza, David A. Fiellin, Lisa A. Marsch   +24 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source