Results 111 to 120 of about 35,694,027 (314)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Een inventariserend veldonderzoek (IVO-O) door middel van mechanische boringen en dateringen

, 2017
Een inventariserend veldonderzoek (IVO-O) door middel van mechanische boringen en ...
EARTH Integrated Archaeology B.V.
core   +1 more source

Integrated assessment and classification of inland water chemistry in New Zealand

Heliyon
Understanding freshwater characteristics is essential for the ecological and environmental management of water resources. New Zealand was selected as the research area, and a water chemistry survey was conducted on freshwater resource management ...
Kei Nakagawa, Hiroki Amano, Channa Rajanayaka, Jing Yang   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Five-CpG-based prognostic signature for predicting survival in hepatocellular carcinoma patients

Cancer Biology & Medicine, 2018
Objective: Hepatocellular carcinoma (HCC) is a common malignancy associated with high morbidity and mortality rates worldwide. Early diagnosis plays an important role in the improvement of HCC prognosis.Methods: In this study, we conducted a ...
Feng Fang, Xiaoqing Wang, Tianqiang Song
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries [PDF]

, 2016
World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB prevention and control among persons living ...
M Katherine Charles, Barbara Castelnuovo (10700), Nguyen Thi Dung, Divine Avit-Edi, Cortés Moncada, Claudia, IeDEA, Ballif, Marie, Nakigozi, Gertrude, Marie Ballif, Durier, Nicolas, Dusingize, Jean Claude, Charles, M Katherine, Nguyen, Thi Dung, Wester, C William, ,, Meridith Blevins, Dung, Nguyen Thi, Cortes, Claudia P, Cortes, Claudia P., Fenner, Lukas, C William Wester, Wester, C. William, Jean Claude Dusingize (473718), Divine Avit-Edi (2609464), Claudia P. Cortes (473719), Mary Lou Lindegren (2609461), Lindegren, Mary Lou, Gertrude Nakigozi, Charles, M. Katherine, Gertrude Nakigozi (247948), C. William Wester (250717), Timothy R. Sterling (148936), Lukas Fenner, Marie Ballif (368655), Blevins, Meridith, Nicolas Durier (326615), Jean Claude Dusingize, Claudia P Cortes, Avit-Edi, Divine, Sterling, Timothy R., Nguyen Thi Dung (245054), Nicolas Durier, Castelnuovo, Barbara, Timothy R Sterling, International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration, Mary Lou Lindegren, Barbara Castelnuovo, Lukas Fenner (149822), Sterling, Timothy R, Meridith Blevins (291088), M. Katherine Charles (2609458)   +50 more
core   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Integrated Crop Management Conference Provides Latest Research and Technologies to Benefit Your Operation [PDF]

, 2015
The annual Integrated Crop Management Conference will be held Dec. 2-3, 2015 at the Scheman Building on the Iowa State University campus. This year, the conference has added additional speakers to its program, providing topics and information on the ...
Integrated Crop Management News
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