Results 191 to 200 of about 35,694,027 (314)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Multi-Proteomic Insights into Lysine Propionylation and Malonylation Remodeling in PRRSV-Infected Porcine Lungs. [PDF]

Vet Sci
Feng Y, Chen D, Liu H, Qiao M, Xu Z, Mei S, Peng X, Wu J.   +7 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Metal-organic framework-based wearable electrochemical glucose sensors for sweat analysis: materials design, sensing mechanisms, and future perspectives. [PDF]

RSC Adv
Krishnamoorthy P, Rajendran AR.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ITARA research programme: Investigating Integrated Tuberculosis And Respiratory care in Africa using transdisciplinary methods. [PDF]

BMJ Open
Meghji J, Engel N, Kagima W, Kinya I, Kionga Y, Lesosky M, Liyoyo A, Madan J, Mpagama S, Obase Ehrim J, Ogundare A, Ozoh O, Orina F, Parker Allen J, Paul EK, Potts J, Tuwabunze L, Yates N, Chakaya Muhwa J, ITARA Consortium, ITARA Consortium .   +20 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Agricultural practices drive multifactorial pyrethroid resistance in Anopheles coluzzii populations from southern Benin. [PDF]

Trop Med Health
Boko MP, Tokponnon F, Ahouandjinou MJ, Diloma SD, Hougbe SZ, Affolabi ZK, Dabou ZS, Fassinou AJ, Sagbohan H, Towakinou L, Vigninou E, Houndeton CS, Dayou SE, Namountougou M, Ossé RA, Akogbéto MC.   +15 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Sugammadex for preventIoN oF pOst-operative pulmoNary complIcAtions (SINFONIA): protocol for an embedded mixed-methods process evaluation. [PDF]

BJA Open
Dunn C, Connolly B, Blackwood B, Silversides JA, Emerson LM, SINFONIA investigators.   +5 more
europepmc   +1 more source