Results 201 to 210 of about 35,694,027 (314)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Optimizing Cataract Surgery Workflows Across a Multi-Satellite Tertiary Care Center. [PDF]

Clin Ophthalmol
El Ashry A, El Ashry M, Kang S, Palioura S, Gibbons A, Correa JMM, Ansari ZA, Theotoka D, Yoo SH, Biekman TR, Schwartz SG, Amescua G, Martinez JD.   +12 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Implementation of primary palliative care interventions across six sub-Saharan African countries: understanding contextual determinants and lessons learnt. [PDF]

Fam Med Community Health
Peeler A, Afolabi O, Nkhoma K, Evans C, Namisango E, Abboah-Offei M, Farrant L, Hunter J, Opare-Lokko EB, Boamah Mensah A, Bates MJ, van Breevoort D, Kwaitana D, Mnenula M, Chifamba D, Mupaza L, Harding R.   +16 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Rollout of a care bundle for intracerebral haemorrhage across the North of England: a qualitative study. [PDF]

BMJ Open Qual
Brunton L, Wilson P, Parry-Jones AR.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Evaluation of a Complex Implementation to Shape, Spread, Scale, and Sustain a New Dementia Care Resource for Better, More Integrated Care. [PDF]

Int J Integr Care
Carter C, Rotsaert C, Fernandes P, Holyoke P.   +3 more
europepmc   +1 more source

Report on the integration and synthesis of Study Site results and their potential for upscaling

Report on the integration and synthesis of Study Site results and their potential for ...
openaire   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source