Results 231 to 240 of about 35,694,027 (314)

Public Health in Practice: Implementation of the CDC Lewis Public Health Scholars Programs. [PDF]

J Public Health Manag Pract
Brandt Flores C, Salcedo A, Golston O, Mulkey S, Hoffman T, Trawick C, Belcher H, Buchanich J, Tola J, Little KN, Lichtveld M, Tolbert N, Gordon R, Piercey GW.   +13 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Soil Carbon and Microbial Functioning Reveal Multidimensional Patterns Across a <i>Cedrus libani</i> Afforestation Chronosequence in Mediterranean Karst. [PDF]

Biology (Basel)
Babur E, Yalçıntaş B, Ünsal YT, Kezik U, Akgün B, Yazar E.   +5 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Field Verification and Multi-Site Deployment of a Multi-Sensor Node for Continuous Environmental Monitoring in Commercial Beef Cattle Facilities. [PDF]

Animals (Basel)
Yi G, Wang X, Jiang S, Zhao J, He T, Chen Z.   +5 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Measuring What Matters: Using Participatory Choice Modelling to Understand Preferences for Homelessness Integrated Care. [PDF]

Int J Integr Care
Tinelli M, Rajeendar G, Cornes M, Harris J, Wittenberg R, Clark M.   +5 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Challenges in implementing integrated undergraduate medical curricula across low- and middle-income countries: A scoping review. [PDF]

Pak J Med Sci
Razaq N, Yaman MN, Besar MNA, Sanip S.
europepmc   +1 more source