Results 241 to 250 of about 35,694,027 (314)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Startup activities and challenges implementing an integrated care model for pregnant and postpartum individuals with substance use disorders: a qualitative study. [PDF]

Subst Abuse Treat Prev Policy
Hall JD, Danna MN, Cahen V, Baron A, Cioffi CC, Cohen DJ.   +5 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Implementing a digital audit-and-feedback surveillance system for diabetic ketoacidosis: study protocol for the DEKODE programme. [PDF]

Front Health Serv
Ling Jie Yee A, Persad K, Manta A, Grove A, Kempegowda P.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Sports, culture and tourism in cities along the Beijing-Hangzhou Grand Canal: sustainable development via SWOT analysis and point-axis spatial optimization. [PDF]

Front Sports Act Living
Hongda T, Yonghu Z.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A Standards-Based, Cloud-Hosted CDS System for Gonorrhea Treatment and HIV Screening. [PDF]

Learn Health Syst
Shenvi E, Boxwala A, Shaw S, Berro A, Karki S, Pooser M, Yang JE, Dumitru G, Ocampo J, Tailor A, Kanjilal S, Paredes C, Hao R, Kashyap N, Liebovitz D, Pérez A.   +15 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

An exploratory mixed-methods study using the ELICIT framework to identify stakeholder-informed implementation strategies for a population health platform. [PDF]

BMC Health Serv Res
Madeo AC, Marable J, Kukhareva P, Kohlmann WK, Bradshaw RL, Maxwell W, Martin C, Davis-Rivera L, Ahsan MD, Borsato EP, Elkin EB, Kaphingst KA, Frey MK, Sharaf RN, Kawamoto K, Fiol GD, Schlechter C, Allen CG.   +17 more
europepmc   +1 more source