Results 171 to 180 of about 5,732,396 (306)

Integrated System Built for Small-Molecule Semiconductors via High-Throughput Approaches. [PDF]

J Am Chem Soc, 2023
Wu J, Zhang J, Hu M, Reiser P, Torresi L, Friederich P, Lahn L, Kasian O, Guldi DM, Pérez-Ojeda ME, Barabash A, Rocha-Ortiz JS, Zhao Y, Xie Z, Luo J, Wang Y, Seok SI, Hauch JA, Brabec CJ.   +18 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Utility of the Endoscopic Pressure Study Integrated System in Identifying Silent Gastroesophageal Reflux Disease During Routine Health Check-ups. [PDF]

DEN Open
Nishikawa Y, Inoue H, Yamamoto K, Sakurai T, Okada Y, Ushikubo K, Shigeta K, Tanaka I, Abiko S, Tanabe M, Ito T, Yokoyama N, Uragami N.   +12 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

"MoSpec": A customized and integrated system for model development, verification and validation. [PDF]

PLoS One
Pompa M, Panunzi S, Borri A, D'Orsi L, De Gaetano A.   +4 more
europepmc   +1 more source

An integrated system for the management of environmental data to support veterinary epidemiology. [PDF]

Front Vet Sci, 2023
Mazzucato M, Marchetti G, Barbujani M, Mulatti P, Fornasiero D, Casarotto C, Scolamacchia F, Manca G, Ferrè N.   +8 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

AI-Driven Integrated System for Burn Depth Prediction With Electronic Medical Records: Algorithm Development and Validation. [PDF]

JMIR Med Inform
Rahman MM, Masry ME, Gnyawali SC, Xue Y, Gordillo G, Wachs JP.   +5 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Upcity: Addressing Urban Problems Through an Integrated System. [PDF]

Sensors (Basel)
Silva AAF, Porto AJS, Belo BMC, Cesar CAC.   +3 more
europepmc   +1 more source