Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Polymorphic display and texture integrated systems controlled by capillarity. [PDF]
Sci Adv, 2023 Ha J +6 more
europepmc +1 more source
Integrated Crop Management Conference Provides Latest Research and Technologies to Benefit Your Operation [PDF]
, 2015 The annual Integrated Crop Management Conference will be held Dec. 2-3, 2015 at the Scheman Building on the Iowa State University campus. This year, the conference has added additional speakers to its program, providing topics and information on the ...
Integrated Crop Management News
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
An integrated systems biology approach reveals differences in formate metabolism in the genus Methanothermobacter. [PDF]
iScience, 2023 Casini I +14 more
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Xmath: Object-Oriented CAE for the 90s and beyond
Measurement + Control, 1992 H Mirab, U Milletti
doaj +1 more source
An integrated, systems-wide approach is needed for public-private partnerships to drive genetic innovation in crops. [PDF]
PLoS Biol, 2023 Feuillet C, Eversole K.
europepmc +1 more source