Results 131 to 140 of about 389,974 (269)

Multidimensional customer requirements acquisition based on ontology

open access: yes, 2016
To acquire the demand information comprehensively and facilitate demand information reuse, the research of acquisition and expression of user requirements were carried on based on user's cognitive process, ontology and development law of requirements ...
Zhao, Wu,   +8 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Dynamic integrated modelling of information systems and business process simulation

open access: yes, 2003
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Business processes and information technology are two areas that are very closely related to the sustained competitive advantage in organisations.
Eatock, Julie
core  

Integrated Electronic Warfare Systems aboard the United States Navy 21st Century Warship [PDF]

open access: yes, 2009
The current world geopolitical situation has resulted in an ever increasing number of third-world nations and terrorists states gaining access to advanced military technology and weaponry that was previously limited to first-world nations. The blue water
Artelt, Matthew P   +5 more
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Sustainability of Organic, Integrated and Conventional Farming Systems in Tuscany

open access: yes
Agricultural researchers widely recognise the importance of sustainable agricultural production systems and the need to develop appropriate methods to measure sustainability.
Pacini, Cesare   +3 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

CGIAR Research Program on Integrated Systems for the Humid Tropics

open access: yes, 2012
This program aims to enhance the opportunities for rapid productivity improvements at the system level based on best technologies, with due attention to sustainable use of natural resources and resilience to climate change.
CGIAR Research Program on Integrated Systems for the Humid Tropics
core  

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