Results 41 to 50 of about 35,227 (214)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Enhancing Daily Runoff Prediction via Uniform Design and Meta-Learning Integrated Hyperparameter Optimization Embedded in Transformer

Hydrology
Accurate runoff prediction is an essential foundation for water resource management, flood prevention, and drought warning. Despite the superior performance of deep learning models in runoff prediction, the high-dimensional hyperparameter optimization ...
Wenxue Wang, Liuyang Li, Donghui Su, Xin Zhang, Haibin Tong, Tiantian Shao, Jiaxin Fan   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Analysis, Design, and Implementation of Improved LLC Resonant Transformer for Efficiency Enhancement

Energies, 2018
In battery charging applications, the charger changes its output voltage in a wide range during the charging process. This makes the design of LLC converters difficult to be optimized between the efficiency and the gain range.
Zhenxing Zhao, Qianming Xu, Yuxing Dai, Hanhang Yin   +3 more
doaj   +1 more source

Integrated linear reactor in transformer based on non-orthogonal decoupling method

Energy Reports, 2020
The air-core reactor has the advantage of good linearity and low noise, however the problem of large space occupation. Power filter with the air-core reactor is indispensable with the widespread use of the power electronic devices in electrified ...
Jinwen Xiang, Zhidong Yang, Longfu Luo, Nihan Tong, Chaowei Han, Shengjie Yang   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Mitigation of voltage sag, swell and power factor correction using solid-state transformer b

Alexandria Engineering Journal, 2014
This paper presents a novel topology of solid-state transformer (SST). In the design process, the AC/DC, DC/AC and AC/AC converters have been integrated to achieve higher efficiency. To obtain higher efficiency from other SST with DC-link topologies, the
M.R. Banaei, E. Salary
doaj   +1 more source