Results 41 to 50 of about 3,343,318 (306)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

FEA‐Based Optimisation of an Inserted‐Shunt Integrated Planar Transformer for a Bidirectional CLLLC Resonant Converter

IET Power Electronics
This paper presents an optimisation method for an inserted‐shunt integrated planar transformer based on 3D simulation in Ansys Maxwell. The optimisation objective is enhanced efficiency and power density for the transformer. Thermal analysis verifies the
Sajad A. Ansari, Jonathan N. Davidson, Martin P. Foster   +2 more
doaj   +1 more source

Integrated Fractional-Turn Planar Transformer for MHz and High-Current Applications

IEEE transactions on power electronics, 2023
In megahertz and high-current applications, planar transformers face problems such as significant winding loss and limited winding current-carrying capacity, which seriously restrict the converter's efficiency and power density improvement.
Kangping Wang, Qingyuan Gao, Gaohao Wei, Xu Yang   +3 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Model transformations and tool integration [PDF]

Software & Systems Modeling, 2005
Model transformations are increasingly recognised as being of significant importance to many areas of software development and integration. Recent attention on model transformations has particularly focused on the OMGs Queries/Views/Transformations (QVT) Request for Proposals (RFP).
openaire   +3 more sources

Ultrahigh dynamic range and low noise figure programmable integrated microwave photonic filter

Nature Communications, 2022
The authors demonstrate programmable integrated microwave photonic filters with low noise figure and ultrahigh dynamic range, using combination of modulation transformer and double injection ring resonator in a single photonic chip.
Okky Daulay, Gaojian Liu, Kaixuan Ye, Roel Botter, Yvan Klaver, Qinggui Tan, Hongxi Yu, Marcel Hoekman, Edwin Klein, Chris Roeloffzen, Yang Liu, David Marpaung   +11 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source