Results 51 to 60 of about 35,227 (214)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A New Subject-Sensitive Hashing Algorithm Based on Multi-PatchDrop and Swin-Unet for the Integrity Authentication of HRRS Image

ISPRS International Journal of Geo-Information
Transformer-based subject-sensitive hashing algorithms exhibit good integrity authentication performance and have the potential to ensure the authenticity and convenience of high-resolution remote sensing (HRRS) images.
Kaimeng Ding, Yingying Wang, Chishe Wang, Ji Ma   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Comprehensive control strategy considering transformer health operation of novel power system distribution network under frequent power flow switching

Diance yu yibiao
With the construction of the novel power system, a large proportion of renewable energy is being integrated into the distribution network, changing the internal power flow of the distribution network, resulting in frequent power switching occurring ...
ZHU Mengzhao, HUANG Xinjie, GU Zhaoliang, ZHU Wenbing, FANG Sidun, YANG Lijun   +5 more
doaj   +1 more source

Analysis and research on the fault-tolerant performance of the high-frequency isolated energy conversion link for an integrated distribution transformer system

The Journal of Engineering, 2019
In order to enhance the stability of the integrated distribution transformer system (IDTS), a fault-tolerant topology of the high-frequency (HF) isolated energy conversion link which features a multi-winding HF transformer and two multi-arm converters ...
Qingshan Wang, Deliang Liang, Yibin Liu, Qixu Chen, Mingkang Zhang   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Double B-type magnetic integrated transformer based input-parallel output-parallel LLC resonant converter modules

Frontiers in Energy Research
The LLC resonant converter used in high-power situations suffers from the problems of high conduction loss and current stress, which can be solved using input-parallel output-parallel (IPOP)-connected converter modules.
Nenghong Xia, Shuang Yan, Huaqi Ma, Xike Mao, Mengqi Chen   +4 more
doaj   +1 more source

Design of Micro-Transformer in Monolithic Technology for High Frequencies Fly-back Type Converters

Electrica, 2018
This article describes the design of amicro-transformer in monolithic technology for high frequencies comprisingplanar type coil and a magnetic circuit made of several layers of materials.This micro-transformer is integrated into a micro-converter of fly-
Abdeldjebbar Abdelkader, Hamid Azzedine
doaj   +1 more source