Results 71 to 80 of about 35,227 (214)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Multi-Branch Residual Multiscale CNN Based Power Transformer Fault Diagnosis on Vibration Signal

CSEE Journal of Power and Energy Systems
Status of the transformer is highly associated with safe and stable operation of the whole power system. Since the vibration signal is generated along with operation of the transformer and can indicate change of equipment operation status in real-time ...
Binwen Zhang, Fei Jiao, Jie Tong, Yuanpeng Tan, Zhonghao Zhang, Shuang Lin   +5 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Client: Cross-variable linear integrated enhanced transformer for multivariate long-term time series forecasting

AI Open
Long-term time series forecasting (LTSF) is crucial in modern society, playing a pivotal role in facilitating long-term planning and developing early warning systems. While many Transformer-based models have recently been introduced for LTSF, a doubt has
Jiaxin Gao, Wenbo Hu, Dongxiao Zhang, Yuntian Chen   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Three-phase autonomous optimization method for distribution transformer areas based on power distribution and utilization edge agents

电力工程技术
The introduction of edge intelligence technology to offload partial power services to the distribution station side serves as an effective technical pathway for distributed smart grid construction at the medium- and low-voltage distribution network level.
Ning GUO, Tuo JI, Yubo YUAN, Chuang ZHOU, Xiaolong XIAO, Shufeng DONG   +5 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TransDeep: Transformer-Integrated DeepLabV3+ for Image Semantic Segmentation

IEEE Access
In recent years, image semantic segmentation algorithms have made significant progress driven by deep learning technology, and are widely used in fields such as medical image analysis, assistive technology for the visually impaired people, and autonomous
Tengfei Chai, Zhiguo Xiao, Xiangfeng Shen, Qian Liu, NianFeng Li, Tong Guan, Jia Tian   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source