Results 81 to 90 of about 3,343,318 (306)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The alchemical integral transform revisited

The Journal of Chemical Physics
We recently introduced the Alchemical Integral Transform (AIT), enabling the prediction of energy differences, and guessed an ansatz to parameterize space r in some alchemical change λ. Here, we present a rigorous derivation of AIT’s kernel K and discuss the parameterization r(λ) in n dimensions, i.e., necessary conditions, mathematical freedoms, and ...
Simon León Krug, O. Anatole von Lilienfeld   +1 more
openaire   +3 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Multi-Branch Residual Multiscale CNN Based Power Transformer Fault Diagnosis on Vibration Signal

CSEE Journal of Power and Energy Systems
Status of the transformer is highly associated with safe and stable operation of the whole power system. Since the vibration signal is generated along with operation of the transformer and can indicate change of equipment operation status in real-time ...
Binwen Zhang, Fei Jiao, Jie Tong, Yuanpeng Tan, Zhonghao Zhang, Shuang Lin   +5 more
doaj   +1 more source

SwinCNN: An Integrated Swin Transformer and CNN for Improved Breast Cancer Grade Classification

IEEE Access
Breast cancer is the most commonly diagnosed cancer among women, globally. The occurrence and fatality rates are high for breast cancer compared to other types of cancer.
V. Sreelekshmi, K. Pavithran, J. J. Nair
semanticscholar   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Three-phase autonomous optimization method for distribution transformer areas based on power distribution and utilization edge agents

电力工程技术
The introduction of edge intelligence technology to offload partial power services to the distribution station side serves as an effective technical pathway for distributed smart grid construction at the medium- and low-voltage distribution network level.
Ning GUO, Tuo JI, Yubo YUAN, Chuang ZHOU, Xiaolong XIAO, Shufeng DONG   +5 more
doaj   +1 more source

Client: Cross-variable linear integrated enhanced transformer for multivariate long-term time series forecasting

AI Open
Long-term time series forecasting (LTSF) is crucial in modern society, playing a pivotal role in facilitating long-term planning and developing early warning systems. While many Transformer-based models have recently been introduced for LTSF, a doubt has
Jiaxin Gao, Wenbo Hu, Dongxiao Zhang, Yuntian Chen   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source