Results 31 to 40 of about 18,963,430 (244)

Integrating environmental and LULC drivers of groundwater droughts in groundwater-dependent ecosystems: a machine learning (XGBoost)-SEM analysis with ecosystem implications

Ecological Processes
Background Investigating the influencing factors of groundwater drought offers critical insights for the sustainable management of groundwater-dependent ecosystems (GDEs).
Kawawa Banda, Christopher Shilengwe, Imasiku Nyambe   +2 more
doaj   +1 more source

Application of the water accounting plus (WA+) framework for the assessment of water availability and consumption in the Zambezi River Basin (ZRB)

Journal of Hydrology: Regional Studies
Study region: The Zambezi River Basin (ZRB) is a large transboundary basin in south-central Africa shared by eight countries. It provides vital water resources for hydropower, agriculture, ecosystems, and human use across the region.
Micheal Katongo Phiri, Kawawa Banda, Mansoor Leh, Naga Velpuri, Primrose Tinonetsana   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Reduccion de la pobreza por medio de la gestion integrada de las aguas subteraneas y superficiales. In SpanishReducing poverty through integrated management of groundwater and surface water [PDF]

, 2014
The full poverty-fighting potential of existing irrigation schemes is not being realized?largely because of inequitable water distribution and unsustainable land and water management practices.
Global Water Partnership, International Water Management Institute   +1 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Integrated use of the CA–Markov model and the Trends.Earth module to enhance the assessment of land cover degradation

Environmental Systems Research
This study aims to demonstrate the potential of assessing future land cover degradation status by combining the forecasting capabilities of the Cellular-Automata and Markov chain (CA-Markov) models in Idris Selva with the land cover degradation (LCD ...
Henry M. Zimba, Kawawa E. Banda, Stephen Mbewe, Imasiku A. Nyambe   +3 more
doaj   +1 more source

International progresses in integrated water resources management

Shui kexue jinzhan, 2018
Water is a basic natural resource that plays an irreplaceable role in maintaining the integrity of the natural environment and promoting sustainable development.
LI Yuanyuan, CAO Jianting, HUANG Huojian, XING Ziqiang   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Modeling the process of hydromechanical amber extraction

E3S Web of Conferences, 2018
The paper represents a process of hydromechanical amber extraction modeling to obtain input data and substantiate operation parameters of mining equipment to develop the improved hydromechanical technique of amber extraction.
Malanchuk Yevhenii, Moshynskyi Viktor, Korniienko Valerii, Malanchuk Zinovii   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source