Results 131 to 140 of about 20,264,016 (337)

The Sanctuary and the Three Angels' Messages 1844-1863: Integrating Factors in the Development of Seventh-day Adventist Doctrines

, 1995
The topic. The concepts of the cleansing of the sanctuary of Daniel 8:14 and the three angels' messages of Revelation 14:6-12 were viewed by Sabbatarian Adventists as the main integrating factors in the development of their doctrinal system. The purpose.
Alberto R. Timm
semanticscholar   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A typhoon-induced debris flow warning model integrating rainfall thresholds with geological factors

Frontiers in Earth Science
Typhoon-induced debris flows pose a significant threat to the southeastern coastal regions of China. The existing typhoon-induced debris flow warning models, however, are largely limited in the refinement of their rainfall thresholds and in their lack of
Yiming Wang, Yiming Wang, Dengcai Xu, Youjian Yang, Minglang Zhou, Wenqing Chen, Wei Lin   +6 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Finding Liouvillian First Integrals of Rational ODEs of Any Order in Finite Terms

Symmetry, Integrability and Geometry: Methods and Applications, 2006
It is known, due to Mordukhai-Boltovski, Ritt, Prelle, Singer, Christopher and others, that if a given rational ODE has a Liouvillian first integral then the corresponding integrating factor of the ODE must be of a very special form of a product of ...
Yuri N. Kosovtsov
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Financial Risk Prediction Models Integrating Environmental, Social and Governance Factors: A Systematic Review

International Journal of Financial Studies
This systematic review explores the incorporation of Environmental, Social, and Governance (ESG) factors within financial risk prediction models, with a particular focus on Machine Learning (ML), Natural Language Processing (NLP), and Large Language ...
Cristina Caro-González, Daniel Jato-Espino, Yudith Cardinale   +2 more
doaj   +1 more source

The on-line tutorial: developing and evaluating resources and disseminating experience [PDF]

, 2004
This is an ESCalate development project awarded to Kerry Shephard, University of Southampton in 2005. It looked at developing practical approaches to integrating a range of commonly available e-learning tools to facilitate wider use of the On-line ...
Furneaux, Clare, Haslam, Paul, Hutchings, Maggie, Shephard, Kerry   +3 more
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