Results 61 to 70 of about 448,439 (309)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Electronic information resources: integration - integration - integration

open access: yesSerials: The Journal for the Serials Community, 2003
This article describes the ELIN@ service (Electronic Library Information Navigator), a system Lund University Libraries have managed to develop to tackle the problem of integration of electronic information resources, increase the use of these resources and make the administration of the e-resources more efficient.The development of the extended ...
Lotte Jørgensen   +4 more
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Synchronous e-learning integrating multicast applications and adaptive QOS [PDF]

open access: yes, 2008
A new generation of e-learning development, based on synchronous groupware applications integration, providing improved interactivity and pro-human relations, allows richer training experiences far beyond a virtual classroom.
Carvalho, Paulo, Deusdado, Sergio
core   +1 more source

Research on cloud edge coordination technology of demand side resources participating in system control within Energy Internet

open access: yesDianzi Jishu Yingyong, 2021
Energy Internet technology can realize the information fusion of demand side adjustable power load resources, transmission and distribution resources, power generation resources, and play the value benefits of demand side adjustable power load in peak ...
Pan Mingming   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Collaborative management of the Grand Ethiopian Renaissance Dam increases economic benefits and resilience

open access: yesNature Communications, 2021
Integrating river system and economy-wide models in a dynamic, iterative, bidirectional fashion allows assessing some economic impacts of interventions in river systems. Here the authors use this framework to compare water resources management strategies
Mohammed Basheer   +7 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Baetica and the Dressel 20 production An outline of the province's history

open access: yesDialogues d'Histoire Ancienne, 1994
This article tries to think anew the Guadalquivir Valley economy in Roman times through an approach integrating three interrelated levels : the synchronie interrelationship within the resources exploitation system ; its transformations ; and the ...
Pedro Paulo A. Funari
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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