Results 71 to 80 of about 448,439 (309)
ResourcesAccessible freshwater, which is already limited, is threatened by overdemand and mismanagement, and the triple planetary crisis of climate change, biodiversity loss, and pollution is pushing the hydrological cycle out of balance [...]
Barbara Ruffino +2 more
doaj +1 more source
Approach and practice: integrating earth observation resources for data sharing in China GEOSS
International Journal of Digital Earth, 2019 Earth observation data sharing is an essential part of the data lifecycle and plays a critical role in Earth science research. Existing industry data sharing systems are affected by restrictions in distributed resource management and tightly coupled ...
Lianchong Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Integrating Open Educational Resources in Blended Courses
, 2021 Integrating Open Educational Resources in Blended Courses: Presentation at the workshop held at Centre for Educational Excellence, Simon Fraser University, Canada on 25 August ...
Mishra, Sanjaya
core
Joint flow-seismic inversion for characterizing fractured reservoirs: theoretical approach and numerical modeling [PDF]
, 2013 Traditionally, seismic interpretation is performed without any account of the flow behavior. Here, we present a methodology to characterize fractured geologic media by integrating flow and seismic data.
Yingcai Zheng +17 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
An educational services architecture to share e-learning resources [PDF]
, 2011 Today many quality e-learning applications have been developed. They are widely used to cover varied aspects of learning and teaching activities, such as developing learning materials, delivering learning activities, and performing assessment tasks ...
Laine, Teemu +2 more
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source