Results 171 to 180 of about 11,120,616 (283)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Preventing secondary primary malignancies (SPMs) in CAR-T cell therapy through site-specific transgene integration into genomic safe harbors (GSHs). [PDF]

J Transl Med
Safarzadeh Kozani P, Safarzadeh Kozani P.   +1 more
europepmc   +1 more source

Integrative genomic analyses for identification and prioritization of long non-coding RNAs associated with autism

, 2017
Brian Gudenas, Anand K. Srivastava, Liangjiang Wang   +2 more
openalex   +2 more sources

Generalized Stäckel transform and reciprocal transformations for finite-dimensional integrable systems [PDF]

, 2008
Artur Sergyeyev, Maciej Błaszak, Artur Sergyeyev, Maciej Błaszak   +3 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A qualitative study of the experiences of Syrian physicians in Türkiye: the need to strengthen integration. [PDF]

Hum Resour Health
Mohammad A, Rayes D, Canbaz S, Karabey S, Abbara A.   +4 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The impact of supply chain integration on performance: A contingency and configuration approach

, 2010
Barbara B. Flynn, Baofeng Huo, Xiande Zhao   +2 more
semanticscholar   +1 more source

Using a coloring activity to identify children's development of visual-motor integration: an application of artificial intelligence. [PDF]

Ann Med
Huang TY, Chen KL, Lin GH, Huang CY.
europepmc   +1 more source

Classical Affine $${\mathcal{W}}$$-Algebras for $${\mathfrak{gl}_N}$$ and Associated Integrable Hamiltonian Hierarchies [PDF]

, 2016
Alberto De Sole, Victor G. Kac, Daniele Valeri, Alberto De Sole, Victor G. Kac, Daniele Valeri   +5 more
openalex   +1 more source