Results 171 to 180 of about 7,800,417 (330)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
'Who's Johnny?' Anthropomorphic Framing in Human-Robot Interaction, Integration, and Policy
, 2015 Kate Darling
openalex +1 more source
5D partition functions, q-Virasoro systems and integrable spin-chains [PDF]
, 2014 Fabrizio Nieri +3 more
openalex +1 more source
Parenting Stress Among Adolescent Mothers: An Integrative Literature Review
, 2022 Serena Flaherty, Lois S. Sadler
openalex +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders
, 2017 Jing Li +15 more
openalex +2 more sources
Path integration in place cells of developing rats [PDF]
, 2018 Tale L. Bjerknes +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Integrating the Integrated Stress Response
American Journal of Respiratory Cell and Molecular Biology, 2023 Harinath Bahudhanapati, Daniel J. Kass
openaire +2 more sources