Results 151 to 160 of about 4,379,016 (366)

Wandeln oder weichen Herausforderungen der wirtschaftlichen Integration fuer Deutschland

, 1997
Der Band enthaelt die ueberarbeiteten Beitraege einer Tagung, deren Ziel es war, den aktuellen Diskussionsstand um die Rolle der Globalisierung fuer den Wirtschaftsstandort Deutschland zu reflektieren.
Schneider, Hilmar (eds.), Pohl, Ruediger, Institut fuer Wirtschaftsforschung Halle (Germany)   +2 more
core  

A Practical Bearing Failure Detection Method Using a New Efficient Deep Network With the Knowledge Self-Adaptive Evolution

Shock and Vibration
Intelligent fault diagnosis technology based on the deep neural network has shown significant advancements in recent years. However, it is difficult and expensive to deploy a fault diagnosis neural network with a huge number of parameters to an embedded ...
Mengyu Ji, Lijun Chen, Yeming Yao, Xiaoping Wang, Cheng Chang, Yunan Zhou   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

ICI Staff Newsletter "FYI" September 2010

, 2010
The Institute's monthly staff newsletter featuring news of recent activities, accomplishments, and resources. This month's feature story is titled, "ICI a Partner in Culture-Based Arts Integration Project."Institute on Community Integration. (2010).
Institute on Community Integration
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Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Human Systems Integration

, 2011
Purpose: Provide overview of Human Systems Integration (HSI) Inputs to the Capabilities Development Document (CDD), Provide an overview of the Localized Electromagnetic Directed Disrupter Device (LED3) Focus on the 7 HSI domainsApproved for public ...
Chandler, Dawn, Howard, Jimmy, Dachos, John, Springs, Sherry, DeBary-Kesner, Barbara   +4 more
core  

Extraction of Inherent Amplitude Mode from a Light Beam

Advanced Photonics Research
Mode extraction is the inverse process of the double‐beam superposition principle in classical optics. While polarization mode extraction has been successfully demonstrated using an m‐order vector vortex beam, amplitude mode extraction remains a ...
Zhiyang Xia, Xiaoyu Weng, Liwei Liu, Jun He, Changrui Liao, Yiping Wang, Junle Qu   +6 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source