Results 171 to 180 of about 4,379,016 (366)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Integration Strategies of Building the City Image of Hangzhou Asian Games [PDF]

, 2022
Shitao Zhang
openalex   +1 more source

Boundary Vector Cells Encode a Future-Biased Spectrum of Positions in the Rat. [PDF]

Hippocampus
Newman EL, Mashanova-Galikova I, Tiganj Z, Lever C.   +3 more
europepmc   +1 more source

ICI Staff Newsletter "FYI" February 2017

, 2017
The Institute's monthly staff newsletter featuring news of recent activities, accomplishments, and resources.Institute on Community Integration. (2017). ICI Staff Newsletter "FYI" February 2017.
Institute on Community Integration
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Molecular characterization of HPV integrations in high-risk HPV-positive women and development of a prognostic signature based on integration-associated genes for cervical cancer. [PDF]

Infect Agent Cancer
Lyu Q, Zhao J, Chen Y, Xiong J, Wang H, Zhang J, Wang L, He X, Zhang W.   +8 more
europepmc   +1 more source

ICI Staff Newsletter "FYI" April 2016

, 2016
The Institute's monthly staff newsletter featuring news of recent activities, accomplishments, and resources.Institute on Community Integration. (2016). ICI Staff Newsletter "FYI" April 2016. Retrieved from the University Digital Conservancy, https://hdl.
Institute on Community Integration
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Replication Data for "Integration of GPS and InSAR Data for Resolving 3-Dimensional Crustal Deformation"

, 2019
Zheng‐Kang Shen
openalex   +1 more source

AIMHub and AIMTechnology integration results

, 2023
Shinichiro
openalex   +1 more source