Results 141 to 150 of about 8,201,628 (359)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Reliable Assessment of Healthcare Procedures: A Comparison of On-Site and Video-Based Methods
Advances in Medical Education and PracticeMinghui Yi,1 Yao Zhang,2 Fei Wu,1 Shilong Zhang,3 Menghui Hu,1 Changmei Liu,1 Bin Zheng,2 Jinling Yang1 1Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 2Surgical ...
Yi M +7 more
doaj
Transport integration - an impossible dream? [PDF]
, 2010 Transport Integration and an Integrated Transport Policy have been widely espoused for many years, yet remain an ambiguous and ill-defined concept. After featuring strongly in the 1998 Transport Policy White Paper, recently transport integration has ...
Potter, Stephen
core +1 more source
Psychiatria Danubina, 2008 The main purposes of the article are to present the history of integration in psychotherapy, the reasons of the development integrative approaches, and the approaches to integration in psychotherapy. Three approaches to integration in psychotherapy exist: theoretical integration, theoretical eclecticism, and common factors in different ...
openaire +4 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Evaluation of pest control contributions to the production of three major grain crops in China
Crop HealthWheat, rice and maize are three major grain crops in China. In 2024, under the organization of National Agricultural Technology Extension Service Center, the contribution rates of controlling pests (diseases, insect pests and weeds) on these crops to ...
Hui Liu +8 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Water, Health, and Social Technologies: One Million Cisterns Programme Case Study
Annals of Global HealthBackground: This paper focuses on the impacts of climate change on vulnerable ecosystems and its implications for the health and well-being of populations.
José Firmino de Sousa Filho +21 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source