Results 211 to 220 of about 7,800,417 (330)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Demonstration of multiple-wavelength-band photonic integrated circuits using a silicon and silicon nitride 2.5D integration method. [PDF]

Nanophotonics
Fu M, Qiu H, Zhang H, Chen X, Qi J, Zhang Y, Xu Y, Liu S, Gu N, Yu H, Yi W, Li X, Guan X.   +12 more
europepmc   +1 more source

Chemical Species Ontology for Data Integration and Knowledge Discovery

, 2023
Laura Pascazio, Simon D. Rihm, Ali Naseri, Sebastian Mosbach, Jethro Akroyd, Markus Kraft   +5 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Blood-Brain Barrier as an Integration Hub in Alzheimer's Disease: How Microbiota Metabolites Modulate Central Signal Processing. [PDF]

CNS Neurosci Ther
Giangiulio O, Maccarone R.
europepmc   +1 more source

Integrating of electrocoagulation process with submerged membrane bioreactor for wastewater treatment under low voltage gradients

, 2023
Khalid Bani‐Melhem, Maria Elektorowicz, Muhammad Tawalbeh, Abeer Al Bsoul, Ahmed El Gendy, Hesam Kamyab, Mohammad Yusuf   +6 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Exploring the association between the lineages of human papillomavirus type 16 and viral physical status in the development of cervical cancer in Iran. [PDF]

Sci Rep
Karami H, Soleimani-Jelodar R, Khezeli Z, Shoja Z, Arashkia A, Varmazyar S, Jalilvand S.   +6 more
europepmc   +1 more source

Evaluating the Microsatellite Instability of Colorectal Cancer Based on Multimodal Deep Learning Integrating Histopathological and Molecular Data

, 2022
Wenjing Qiu, Jiasheng Yang, Bing Wang, Min Yang, Geng Tian, Peizhen Wang, Jialiang Yang   +6 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source