Results 51 to 60 of about 2,036,053 (317)
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel+2 more
wiley +1 more source
Integrability, non-integrability and confinement [PDF]
We discuss the main features of quantum integrable models taking the classes of universality of the Ising model and the repulsive Lieb-Liniger model as paradigmatic examples. We address the breaking of integrability by means of two approaches, the Form Factor Perturbation Theory and semiclassical methods. Each of them has its own advantage.
openaire +3 more sources
Evolutionary interplay between viruses and R‐loops
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi+4 more
wiley +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez+17 more
wiley +1 more source
Large-scale optical switches by thermo-optic waveguide lens
Optical switches are desired in telecom and datacom as an upgrade to electrical ones for lower power consumption and expenses while improving bandwidth and network transparency.
Tao Chen+5 more
doaj +1 more source
Signal Integrity and Power Integrity [PDF]
The COVID-19 pandemic has brought many changes. Among them, virtual conferences may become a new norm, or at least an important element for future technical symposia. Although we miss the opportunities to socialize with our colleagues and discuss issues face-to-face, virtual conferences can present different, yet still enjoyable, experiences and allow ...
openaire +2 more sources
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao+7 more
wiley +1 more source
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever+1 more
wiley +1 more source
Hoy en día, el estudio académico fragmento al sujeto de estudio para analizarlo desde diferentes perspectivas, así el sujeto presenta variaciones desde los ojos profesionales que lo interpretan y describen.
Jair Hernando Castro+1 more
doaj +1 more source
(Dis)connecting migration: transnationalism and nationalism beyond connectivity
Transnationalism as a perspective that scrutinizes localities in more than one nation-state has helped to illuminate those aspects of lives of migrants that remain hidden when migration is seen through the lens of conventional migration theory.
Magdalena Nowicka
doaj +1 more source