Results 61 to 70 of about 4,379,016 (366)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Point spread function decoupling in computational fluorescence microscopy

Light: Science & Applications
Computational fluorescence microscopy constantly breaks through imaging performance through advanced optical modulation technologies; however, conventional theoretical modeling and experimental measurement approaches are challenging to meet the demand ...
Ziwei Wang, Wanyu Gu, Shaolei Xu, Yupei Miao, Zewei Cai, Xiang Peng, Xiaoli Liu, Liwei Liu, Qifeng Yu   +8 more
doaj   +1 more source

Marcos do desenvolvimento infantil em crianças com necessidades de saúde especiais: relato de uma educação em saúde

Extensio: Revista Eletrônica de Extensão
Relatar a experiência de aplicar uma estratégia de educação em saúde sobre os marcos do desenvolvimento infantil, com acompanhantes de crianças com anomalias congênitas e hospitalizadas por longo período de tempo.
Maria Graciana da Silva Felipe, Leidiane Minervina Moraes de Sabino , Flávia Paula Magalhães Monteiro, Huana Carolina Candido Morais   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A classifier-assisted evolutionary algorithm with knowledge transfer for expensive multitasking problems

Complex & Intelligent Systems
Surrogate-assisted evolutionary algorithms provide an effective means for complex and computationally expensive optimization problems. However, due to the scarcity of training samples, the prediction accuracy of frequently-used regression surrogate ...
Min Hu, Zhigang Ren, Zhirui Cao, Yifeng Guo, Haitao Sun, Hongyao Zhou, Yu Guo   +6 more
doaj   +1 more source

Ohmic Contacts With Ultra-Low Optical Loss on Heavily Doped n-Type InGaAs and InGaAsP for InP-Based Photonic Membranes

IEEE Photonics Journal, 2016
In this paper, we present significant reductions of optical losses and contact resistances in AgGe-based ohmic contacts to InP membranes. Due to the high solubility of Si in InGaAs and InGaAsP, heavily doped n-type contact layers are grown on InP wafers.
L. Shen, P. J. van Veldhoven, Y. Jiao, V. Dolores-Calzadilla, J. J. G. M. van der Tol, G. Roelkens, M. K. Smit   +6 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A universal and versatile terahertz field manipulation mechanism by manipulating near-infrared phases with a dislocation scheme

Nature Communications
This paper presents a universal and versatile terahertz (THz) wavefront-phase manipulation by manipulating the two-dimensional phases of the near-infrared pulses.
Qinggang Lin, Fu Feng, Xuanke Zeng, Yi Cai, Wenzhao He, Congying Wang, Kaipeng Wu, Xiaowei Lu, Hongmei Zhong, Shixiang Xu, Jingzhen Li, Xiaocong Yuan   +11 more
doaj   +1 more source