Results 51 to 60 of about 8,201,628 (359)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Evaluation of the Neuroprotective Potential of Sutherlandia frutescens in a Rotenone-Induced Rat Model of Parkinson’s Disease

Behavioural Neurology
Sutherlandia frutescens (SF) is a plant used traditionally in South Africa for various health conditions, including neurological disorders. Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of ...
Lilit Darbinyan, Karen Simonyan, Larisa Manukyan, Vaghinak Sarkisian, Lusya Hovhannisyan, Lilia Hambardzumyan   +5 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Factors associated with postpartum psychiatric disorders using routine administrative data

International Journal of Population Data Science, 2022
Background Almost twenty percent of women worldwide experience mental health disorders following childbirth. Despite their importance and consequences, postpartum psychiatric disorders are still under-investigated.
Flávia Jôse Oliveira Alves, Luis F Castro-de-Araujo, Erika Fialho Morais Xavier, Daiane Borges Machado, Maurício L Barreto   +4 more
doaj   +1 more source

Separation/Integration [PDF]

, 2014
This programme is built around David C Johnson’s 4-channel tape piece Telefun, realised in the WDR Studio for Electronic Music, Cologne. Gemini 8 is a new work by Sean Williams for Grey Area based on NASA's Gemini missions of the 1960s which paved the ...
Williams, Sean
core  

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Data integration under integrity constraints [PDF]

Information Systems, 2002
Data integration systems provide access to a set of heterogeneous, autonomous data sources through a so-called global schema. There are basically two approaches for designing a data integration system. In the global-as-view approach, one defines the elements of the global schema as views over the sources, whereas in the local-as-view approach, one ...
Andrea Cali, Diego Calvanese, DE GIACOMO, Giuseppe, LENZERINI, Maurizio   +3 more
openaire   +3 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

A novel exergy-based assessment on a multi-production plant of power, heat and hydrogen: integration of solid oxide fuel cell, solid oxide electrolyzer cell and Rankine steam cycle [PDF]

, 2021
Milad Sadeghzadeh, Mehdi Mehrpooya, Hojat Ansarinasab   +2 more
openalex   +1 more source