Results 51 to 60 of about 357,876 (303)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Integration of Inertial Navigation System with EM-log Using H-infinity Filter [PDF]
E3S Web of Conferences, 2019 This paper presents the integration of inertial navigation system (INS) with electromagnetic-log (EM-log) as an underwater navigation system using H-infinity filter for robustness from the uncertainty of the sea current model. In underwater environments,
Cha Jaehyuck +4 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
iPHACE: integrative navigation in pharmacological space [PDF]
Bioinformatics, 2010 Abstract Summary: The increasing availability of experimentally determined binding affinities for drugs on multiple protein targets requires the design of specific mining and visualization tools that graphically integrate chemical and biological data in an efficient environment.
Ricard García-Serna +3 more
openaire +2 more sources
Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
e-Navigation: Challenges and Opportunities [PDF]
, 2009 e-Navigation is a recent IMO initiative that aims to integrate existing/new shipboard and shore-based navigational tools into an “all embracing” system. Defined as: “...
Alexander, Lee
core +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hydrographic Products/Services as a Fundamental Component of the e-Navigation Concept of Operation [PDF]
, 2010 e-Navigation is a recent initiative aimed at moving traditional maritime navigation towards a connected digital environment. Defined by the International Maritime Organization (IMO) as “the harmonized collection, integration, exchange, presentation and ...
Alexander, Lee, Ward, Robert
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
e-Navigation and Electronic Charting: Implications for Hydrographic Community [PDF]
, 2009 e-Navigation is a recent IMO initiative that aims to integrate existing/new shipboard and shore-based navigational tools into an “all embracing” system. Defined as: “...
Alexander, Lee
core +1 more source