Results 81 to 90 of about 1,343,028 (316)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Towards Efficient and Clean Process Integration: Utilisation of Renewable Resources and Energy-Saving Technologies

open access: yesEnergies, 2019
The strong demand for sustainable energy supplies had escalated the discovery, and intensive research into cleaner energy sources, as well as efficient energy management practices.
Jiří Jaromír Klemeš   +3 more
doaj   +1 more source

Special Issue on “Process Design, Integration, and Intensification” [PDF]

open access: yes, 2019
With the growing emphasis on enhancing the sustainability and efficiency of industrial plants, process integration and intensification are gaining additional interest throughout the chemical engineering community [...
Mahmoud El-Halwagi, Dominic C. Y. Foo
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Emerging Tools for Energy System Design Increasing Economic and Environmental Sustainability

open access: yesEnergies, 2020
Energy is a fundamental element supporting societal development, particularly with the increasing dependency on the Internet of Things. It is also the main contributor to environmental impacts and subsequently, a potential sector for mitigation ...
Yee Van Fan   +2 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

PROCESS INTEGRATION AND INTENSIFICATION: SAVING ENERGY AND WATER [PDF]

open access: yes
openThis thesis explores energy efficiency improvement and water treatment optimization through advanced process integration techniques. The first part focuses on heat integration within industrial systems using pinch analysis, grand composite curves ...
TEYROUZ, JOSEPH
core  

A systems engineering perspective on process integration in industrial biotechnology [PDF]

open access: yes, 2015
Biotechnology has many applications in health care, agriculture, industry and the environment. By using renewable raw materials, biotechnology contributes to lowering greenhouse gas emissions and moving away from a petro-based towards a circular ...
Kiss, Anton A.   +5 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

The Eurasian Integration as an Example of Modern Integration Process in the Conditions of Instability

open access: yesУправленческое консультирование, 2018
In the article, the concept of the Eurasian integration as a modern priority in the field of development and modernization is considered. In this work integration is investigated not so much as coordination of economic procedures but as formation not ...
Andrey Andreevich Kovalev
doaj   +1 more source

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