Results 101 to 110 of about 14,082,827 (312)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

A Deep Learning-Based Acoustic Signal Analysis Method for Monitoring the Distillation Columns’ Potential Faults

open access: yesApplied Sciences
Distillation columns are vital for substance separation and purification in various industries, where malfunctions can lead to equipment damage, compromised product quality, production interruptions, and environmental harm. Early fault detection using AI-
Honghai Wang   +3 more
doaj   +1 more source

EUROPEAN UNION INTEGRATION PROCESS: A LESSON LEARNED FOR ASEAN

open access: yesJurnal Hukum Internasional, 2016
The paper first highlights the historical background of Indonesian foreign policy, the current “downto-earth and pro-people diplomacy”, as well as Indonesian foreign policy for the period of 2015-2019.
Leonard Felix Hutabarat
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Covalent Bonds Reinforced Strength and Modulus of Heterocyclic Aramid Fiber by Interfacial Aminated‐MXene Nanosheets

open access: yesAdvanced Science
Architecting high‐performance heterocyclic poly(p‐phenylene benzimidazole‐benzamide) (PBIA) fiber presents challenges, including low orientation, crystallinity and interchain interaction, which reduces mechanical property.
Boyuan Chen   +7 more
doaj   +1 more source

Neorealistyczne interpretacje procesu integracji europejskiej

open access: yesHistoria i Polityka, 2015
Taking place within the European Union integration processes are the subject of research of many theorists of the European integration. On the basis of the social sciences, there are many theoretical approaches which try to explain the phenomenon of ...
Marzena Orłowska
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

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