Results 111 to 120 of about 14,082,827 (312)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Institute on Community Integration Annual Report: 2010-11
, 2011 The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Center for Excellence in Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
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, 2011 This volume contains the proceedings of the 3rd Workshop on Model Driven Tool and Process Integration held on 16 June 2010 in Paris, France, in conjunction with the European Conference on Modeling Foundations and Applications (ECMFA 2010).
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The role of process integration techniques in the thermo-economic optimization of energy conversion systems [PDF]
Within the goal of reducing greenhouse gas emissions and supplying sustainable energy, complex integrated energy conversion systems have to be designed by taking into account thermodynamic, economic and environmental considerations simultaneously.
Tock, Laurence, Maréchal, François
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Institute on Community Integration Annual Report: 2009-10
, 2010 The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Center for Excellence in Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Institute on Community Integration Annual Report: 2011-12
, 2012 The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Center for Excellence in Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core