Results 131 to 140 of about 1,343,028 (316)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Beyond the rhetoric: a theoretical analysis of the effects of neopatrimonialism and intergovernmentalism on the integration process in Africa [PDF]
, 2014 The Organization of African Unity marked its 50th anniversary in 2013 and, despite the shift to the African Union and continued rhetoric from African leaders about the need for further integration, the progress towards the goal of economic and political ...
Duthie, Shawn
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The governance of regional networks in the process of European integration [PDF]
The paper illustrates the model of territorial networks and it investigates the role of institutions in a bottom-up approach of economic and institutional integration aiming to tackle the negative impacts of the globalization process on the economic ...
Riccardo Cappellin
core
The fog of integration: Reassessing the role of economic interests in European integration [PDF]
, 2007 The main theories of European economic integration argue that private economic interests play an important role in the integration process. This role is a positive one, whereby economic interests provide the impetus and pressures for integration to move ...
Patrick Leblond, Leblond, Patrick.
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Electrochemical Nitrate Reduction Reaction to Ammonia at Industrial‐Level Current Densities
Advanced ScienceThe electrochemical nitrate reduction reaction (NO3−RR) represents a promising green synthesis technology, enabling both resource utilization of nitrate (NO3−) pollutants in wastewater and provision of a sustainable ammonia (NH3) source for carbon ...
Zhijie Cui +4 more
doaj +1 more source