Results 131 to 140 of about 4,517,998 (308)
Dynamic integration of context model constraints in web service processes [PDF]
, 2009 Autonomic Web service composition has been a challenging topic for some years. The context in which composition takes places determines essential aspects. A context model can provide meaningful composition information for services process composition. An
Bandara, Kosala Yapa +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mercosur: past, present, and future [PDF]
In March 2003, the Southern Common Market (Mercosur) celebrated its twelfth anniversary. In twelve years, the bloc went from a substantially restricted trade structure to a practically free-trade area, with additional efforts in establishing a customs ...
Paulo Paiva, Ricardo Gazel
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
An ontology-based documentation of data discovery and integration process in cancer outcomes research. [PDF]
BMC Med Inform Decis Mak, 2020 Zhang H, Guo Y, Prosperi M, Bian J.
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Regulation of Competition and Innovation in the European Union and Spain: Opportunities for the Philippines and the ASEAN [PDF]
, 2016 The Philippines are currently facing a process of regional economic integration inside the ASEAN, in some way similar to the process undertaken by Spain and the European Union decades ago.
Olmedo-Peralta, Eugenio
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source