Results 71 to 80 of about 3,162,958 (354)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The Integration Order of Vector Autoregressive Processes [PDF]
We show that the order of integration of a vector autoregressive process is equal to the difference between the multiplicity of the unit root in the characteristic equation and the multiplicity of the unit root in the adjoint matrix polynomial.
Massimo Franchi
core
A conceptual model for EAI adoption in an e-government environment [PDF]
, 2006 The non-integrated nature of Local Government Authority (LGA) Information Systems (IS) is strongly associated with the inconsistency and duplication of data, reduction in data integrity and quality, and high operational and maintenance cost. The reason
Kamal, M, Themistocleous, M
core
Data-driven modelling of biological multi-scale processes
, 2015 Biological processes involve a variety of spatial and temporal scales. A holistic understanding of many biological processes therefore requires multi-scale models which capture the relevant properties on all these scales.
Hasenauer, Jan +3 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
RUDN Journal of Public AdministrationThe study discusses the issues related to the institutional mechanisms of integration of the Kherson region into the political, administrative and socio-economic space of the Russian Federation.
Elena A. Mitrofanova +2 more
doaj +1 more source
IT based integration business processes [PDF]
Peer-to-Peer (P2P) computing represents the next revolution in the computing age. Web Services standardization will provide the means for P2P architecture to be broadly adopted by companies for enterprise and business-to-business application integration ...
Radu Lixandroiu
core
Service architecture design for E-Businesses: A pattern-based approach [PDF]
, 2008 E-business involves the implementation of business processes over the Web. At a technical level, this imposes an application integration problem. In a wider sense, the integration of software and business levels across organisations becomes a significant
Gacitua-Decar, Veronica, Pahl, Claus
core