Results 81 to 90 of about 704,715 (267)

The effects of forest canopy shading and turbulence on boundary layer ozone

open access: yesNature Communications, 2017
Fully quantifying the influence of vegetation on atmospheric chemistry remains challenging. Here, the authors show that forest canopy shading and turbulence significantly modify air pollution throughout the atmospheric boundary layer, and must be taken ...
P. A. Makar   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

THE PROCESSES OF REORGANIZATION IN THE MODERN EDUCATION SYSTEM

open access: yesВестник университета, 2017
The history of integration processes in education and global experience in the consolidation of universities are discussed in the article. The objectives are defined, the main reasons of mergers and acquisitions in higher education are listed.
K. Balkizova
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

THE PROCESSES OF REORGANIZATION IN THE MODERN EDUCATION SYSTEM

open access: yesВестник университета, 2019
The history of integration processes in education and global experience in the consolidation of universities are discussed in the article. The objectives are defined, the main reasons of mergers and acquisitions in higher education are listed.
K. Balkizova
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

The Geopolitical Factor in the Integration of Mediterranean and Black Sea States: Problems and Perspectives

open access: yesRUDN Journal of World History, 2009
The article deals with the Mediterranean and Black Sea region, its place and role in international relations and world policy. Special attention is given to security problems, integration processes and the factors of stable development of the region.
E M Savicheva
doaj  

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