Results 181 to 190 of about 839,923 (314)

[Integrative and complementary practices, hypertension and social indicators: an ecological study, Brazil, 2023]. [PDF]

Epidemiol Serv Saude
do Nascimento ADSF, de Souza MCL, Rossoni SL, Dos Santos JH, Lopes WA, Pujals C, Pedroso RB.   +6 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Predictors, prevalence and economic burden of depression and anxiety in Vietnam and comparable lower-middle-income countries in Southeast Asia: protocol for an integrative review. [PDF]

BMJ Open
Donnelly TT, Vu TP, Nguyen TMH, Nguyen QG, Tran NK, Le HHB, Tang DM.   +6 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Descriptive analysis and program evaluation of a model pain coach educator and integrative toolkit program in an urban hospital system. [PDF]

PEC Innov
Hendry P, Sheikh S, Curtis ME, Crisp AM, Li RM, Maples K, Chitty L, Warrick M, Montague M, Lott M, Cleveland L, Dabhi K, Menze N, Munson T, Feeney S, Gage CN.   +15 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

A conditional threat-regulation model: When deliberative processing of ongoing threat reduces intergroup bias. [PDF]

PNAS Nexus
Tadmor CT, Chao MM, Hong YY, Cai LY.
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Manifestations and Impacts of Racial Aggressions on Black Individuals' Health and Well-Being in University Settings Across Organization for Economic Cooperation and Development Countries: Protocol for an Integrative Review. [PDF]

JMIR Res Protoc
Ntanda GM, Lapierre J, Bouabdillah N, Tavalica VL, Rouleau G, Ndjaboue R, Sia D, Stake-Doucet N, Seguin C, Lafortune G, Philibert L.   +10 more
europepmc   +1 more source