Results 81 to 90 of about 6,800,285 (350)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Integrative medicine in Dutch curative and long-term healthcare centres : Mapping the field
, 2019 Introduction: Little is known about integration of Complementary and Alternative Medicine (CAM) in the Dutch healthcare system. The aim of the present study was to investigate how Integrative Medicine (IM) is practiced and how CAM is integrated with ...
Baars, Erik W., +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Integrative Medicine: In With the New
Journal of Patient-Centered Research and Reviews, 2015 Integrative medicine is not "alternative," which implies the substitution of conventional medicine with often unproven natural treatments. Rather, integrative medicine is defined as the combination of conventional biomedicine with nontraditional and ...
Tiffany A. Mullen
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Women’s mental health and complementary and integrative medicine
, 2020 The aim of this chapter is to explore complementary and integrative medicine (CIM) use for the two most prevalent mental health conditions: depression and anxiety.
Lauche R, Frawley J, McIntyre E
core
Meta-analysis in systematic reviews of complementary and integrative medicine trials
, 2016 © 2017 Elsevier Ltd In evidence-based medicine, meta-analyses are often considered to provide an exceptionally high level of evidence. Beyond other systematic review formats, meta-analyses allow for statistically pooling results of original research ...
Cramer, H +3 more
core +1 more source
, 2021 Global interest in complementary and integrative medicine (CIM) has risen exponentially over recent decades, with recent research from a number of countries indicating that this interest in CIM may also extend to pregnancy (Frawley et al. 2013).
Frawley, J +4 more
core +1 more source
Integrative Medicine and the Quest for Humanism in Medicine [PDF]
Forschende Komplementärmedizin / Research in Complementary Medicine, 2011 The recent issues of this journal have repeatedly presented considerations on the use and appropriateness of the term ‘integrative medicine’ (IM) and its relatives such as ‘complementary medicine’ (CM), ‘complementary and alternative medicine’ (CAM), ‘integrative and complementary medicine’ (CIM).
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source