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Holistic Integrative Medicine Declaration [PDF]

Zhongguo quanke yixue
Holistic integrative medicine, abbreviated as HIM, has been officially proposed since 2012. Its theoretical system has been continuously improved, and its practical methods have become increasingly diverse, becoming an inevitable choice and path for the ...
China Institute for Development Strategy of Holistic Integrative Medicine
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Tension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration

Cell Death and Disease, 2022
The microtubule (MT) plus-end binding protein Clip170 is associated closely with breast cancer invasion and migration. In this study, Clip170 tension observed by a newly designed cpstFRET tension probe was suggested to be positive related to breast ...
Yunfeng Hu, Qiu Xie, Xiang Wu, Weizhen Liu, DongFang Li, Chen Li, WangXing Zhao, LinLin Chen, Zihui Zheng, GuangMing Li, Jun Guo   +10 more
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Protein nanoparticle-induced osmotic pressure gradients modify pulmonary edema through hyperpermeability in acute respiratory distress syndrome

Journal of Nanobiotechnology, 2022
Acute respiratory distress syndrome (ARDS), caused by noncardiogenic pulmonary edema (PE), contributes significantly to Coronavirus 2019 (COVID-19)-associated morbidity and mortality.
ZhiZhi Qian, QianYi Wang, ZhaoShun Qiu, DanYang Li, ChenCheng Zhang, XiYu Xiong, ZiHui Zheng, QinLi Ruan, YiChen Guo, Jun Guo   +9 more
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Serum hsa-miR-98-5p and RORC may be new biomarkers related to esophageal cancer [PDF]

E3S Web of Conferences, 2021
This study aims to use bioinformatics methods to discover new serum miRNA markers for esophageal cancer, and provide a theoretical basis for early diagnosis of esophageal cancer. We used GEO2R to analyze the differential serum miRNAs in esophageal cancer
Zhou Zheyu, Wang Yinyu, Li Wenwen, Xia Haoyang, Han Gaohua   +4 more
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Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation

Cell Death and Disease, 2022
Human sideroflexin 2 (SFXN2) belongs to the SFXN protein family, which is a mitochondrial outer membrane protein involved in mitochondrial iron metabolism. Mitochondria are indispensable for cellular energy production and iron metabolism.
Ying Chen, Jinjun Qian, Pinggang Ding, Wang Wang, Xinying Li, Xiaozhu Tang, Chao Tang, Ye Yang, Chunyan Gu   +8 more
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AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

Journal of Experimental & Clinical Cancer Research, 2022
Background Currently, multiple myeloma (MM) is still an incurable plasma cell malignancy in urgent need of novel therapeutic targets and drugs. Methods Bufalin was known as a highly toxic but effective anti-cancer compound.
Chunyan Gu, Yajun Wang, Lulin Zhang, Li Qiao, Shanliang Sun, Miaomiao Shao, Xiaozhu Tang, Pinggang Ding, Chao Tang, Yuhao Cao, Yanyan Zhou, Mengjie Guo, Rongfang Wei, Nianguang Li, Yibei Xiao, Jinao Duan, Ye Yang   +16 more
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Structures of the CcmABCD heme release complex at multiple states

Nature Communications, 2022
Bacterial ABC transporter complex CcmABCD, a part of cytochrome c maturation system, transfers heme from one binding partner (CcmC) to another (CcmE). Here authors describe high resolution cryo-EM structures of CcmABCD in multiple states and propose a ...
Jiao Li, Wan Zheng, Ming Gu, Long Han, Yanmei Luo, Koukou Yu, Mengxin Sun, Yuliang Zong, Xiuxiu Ma, Bing Liu, Ethan P. Lowder, Deanna L. Mendez, Robert G. Kranz, Kai Zhang, Jiapeng Zhu   +14 more
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Study on metastasis inhibition of Kejinyan decoction on lung cancer by affecting tumor microenvironment

Cancer Cell International, 2020
Background Kejinyan decoction, as an experienced formula of Zhou Zhongying (the Master of Traditional Chinese Medicine) has been widely used in clinic for lung cancer treatment in China, while the anti-lung cancer mechanism of it is still remained to be ...
Meijuan Chen, Cheng Hu, Qian Gao, Liqiu Li, Ziyu Cheng, Qirui Li, Zhihui Li, Zhaohui Wang, Zejia Mao, Weiqian Tian, Xu Zhang   +10 more
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Alteration of gastric microbiota and transcriptome in a rat with gastric intestinal metaplasia induced by deoxycholic acid

Frontiers in Microbiology, 2023
ObjectiveBile reflux plays a key role in the development of gastric intestinal metaplasia (GIM), an independent risk factor of gastric cancer. Here, we aimed to explore the biological mechanism of GIM induced by bile reflux in a rat model.MethodsRats ...
Zijing Xu, Ling Xiao, Shuaishuai Wang, Yuqin Cheng, Jianping Wu, Yufen Meng, Kaifan Bao, Junfeng Zhang, Chun Cheng   +8 more
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Treatment of COVID-19 by monoclonal antibodies and the traditional Chinese medicine

Medicine in Novel Technology and Devices, 2022
The mortality rate of the recent global pandemic corona virus disease 2019 (COVID-19) is currently as high as 7%. The SARS-CoV-2 virus is the culprit behind COVID-19.
Yuyan Ling, Yuxuan Dong, Qirui Li, Doudou Huang, Zhihui Li, Meijuan Chen   +5 more
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