Results 11 to 20 of about 19,838 (208)

Aquaporin-9 facilitates liver regeneration following hepatectomy

Redox Biology, 2022
Aquaporin-9 (AQP9) is an aquaglyceroporin strongly expressed in the basolateral membrane of hepatocytes facing the sinusoids. AQP9 is permeable to hydrogen peroxide (H2O2) and glycerol as well as to water.
Bo Zhang, Dongyue Lv, Yang Chen, Weijue Nie, Yang Jiao, Junqi Zhang, Xiaoxiao Zhou, Xiao Wu, Siqing Chen, Tonghui Ma   +9 more
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Mechanism investigation of Caspase-8/GSDMC dependent immunogenic cell death induced by Ophiopogonin B in NSCLC cells

Pharmacological Research - Modern Chinese Medicine, 2022
Ophiopogonin B (OP-B) as a bioactive component of Radix Ophiopogon Japonicus has been reported to induce various kinds of cell death of non-small cell lung cancer (NSCLC) cells, while the underline mechanism is unknown.
Zhihui Li, Ling Gu, Qian Gao, Liqiu Li, Maozheng Sheng, Yuyan Ling, Cheng Hu, Menglin He, Xiongfei Zhang, Xu Shen, Xu Zhang, Meijuan Chen   +11 more
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Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The non-receptor protein tyrosine phosphatase (PTP) SHP2 encoded by the PTPN11 gene is a critical regulator in a number of cellular signalling processes and pathways, including the MAPK and the immune-inhibitory programmed cell death PD-L1/PD-1 pathway ...
Yanmei Luo, Jin Li, Yuliang Zong, Mengxin Sun, Wan Zheng, Jiapeng Zhu, Liu Liu, Bing Liu   +7 more
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BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability

Signal Transduction and Targeted Therapy, 2021
Multiple myeloma (MM) is an incurable plasma cell malignancy in the bone marrow characterized by chromosome instability (CIN), which contributes to the acquisition of heterogeneity, along with MM progression, drug resistance, and relapse.
Xiaozhu Tang, Mengjie guo, Pinggang Ding, Zhendong Deng, Mengying Ke, Yuxia Yuan, Yanyan Zhou, Zigen Lin, Muxi Li, Chunyan Gu, Xiaosong Gu, Ye Yang   +11 more
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Induction of Ferroptosis by Ophiopogonin-B Through Regulating the Gene Signature AURKA in NSCLC

Frontiers in Oncology, 2022
Ferroptosis is a new type of iron-dependent programmed cell death. In recent years, its role in the diagnosis and treatment of multiple tumors, including non-small cell lung cancer (NSCLC), has been continuously observed.
Liqiu Li, Liqiu Li, Qian Gao, Jin Wang, Ling Gu, Ling Gu, Zhihui Li, Shiping Zhang, Cheng Hu, Menglin He, Yulin Wang, Zixuan Wang, Yongxiang Yi, Jin Fu, Xiongfei Zhang, Fei Ge, Meijuan Chen, Xu Zhang   +17 more
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HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA

Journal of Hematology & Oncology, 2021
N6-methyladenosine (m6A) modification is the most prevalent modification in eukaryotic RNAs while accumulating studies suggest that m6A aberrant expression plays an important role in cancer.
Fengjie Jiang, Xiaozhu Tang, Chao Tang, Zhen Hua, Mengying Ke, Chen Wang, Jiamin Zhao, Shengyao Gao, Artur Jurczyszyn, Siegfried Janz, Meral Beksac, Fenghuang Zhan, Chunyan Gu, Ye Yang   +13 more
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Review on circular RNAs and new insights into their roles in cancer

Computational and Structural Biotechnology Journal, 2021
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA molecules derived from exonic or intronic sequences by precursor mRNA back-splicing.
Xiaozhu Tang, Hongyan Ren, Mengjie Guo, Jinjun Qian, Ye Yang, Chunyan Gu   +5 more
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BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans

Frontiers in Pharmacology, 2023
Introduction: BuShen HuoXue (BSHX) decoction is commonly used in the clinical treatment of premature ovarian failure because it can increase estradiol level and decrease follicle-stimulating hormone level.
Kanglu Wu, Xudong Zhao, Xian Xiao, Miao Chen, Liang Wu, Chao Jiang, Jing Jin, Lei Li, Qinli Ruan, Jun Guo   +9 more
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Gold(I) selenium N-heterocyclic carbene complexes as potent antibacterial agents against multidrug-resistant gram-negative bacteria via inhibiting thioredoxin reductase

Redox Biology, 2023
Multidrug-resistant (MDR) Gram-negative bacteria have become a global threat to human life and health, and novel antibiotics are urgently needed. The thioredoxin (Trx) system can be used as an antibacterial target to combat MDR bacteria.
Xiuli Chen, Shibo Sun, Sheng Huang, Han Yang, Qing Ye, Lin Lv, Yanshan Liang, Jinjun Shan, Jianqiang Xu, Wukun Liu, Tonghui Ma   +10 more
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Steroid 5α-Reductase Type I Induces Cell Viability and Migration via Nuclear Factor-κB/Vascular Endothelial Growth Factor Signaling Pathway in Colorectal Cancer

Frontiers in Oncology, 2020
Colorectal cancer (CRC) is a common malignant tumor of the digestive system. Steroid 5α-reductase type I (SRD5A1), as an important part of the steroid metabolism, converts testosterone to dihydrotestosterone and regulates sex hormone levels, which ...
Rongfang Wei, Rongfang Wei, Sixia Zhong, Li Qiao, Mengjie Guo, Miaomiao Shao, Suyu Wang, Bin Jiang, Ye Yang, Chunyan Gu, Chunyan Gu   +10 more
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