Results 21 to 30 of about 20,496 (277)

Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The non-receptor protein tyrosine phosphatase (PTP) SHP2 encoded by the PTPN11 gene is a critical regulator in a number of cellular signalling processes and pathways, including the MAPK and the immune-inhibitory programmed cell death PD-L1/PD-1 pathway ...
Yanmei Luo, Jin Li, Yuliang Zong, Mengxin Sun, Wan Zheng, Jiapeng Zhu, Liu Liu, Bing Liu   +7 more
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HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA

Journal of Hematology & Oncology, 2021
N6-methyladenosine (m6A) modification is the most prevalent modification in eukaryotic RNAs while accumulating studies suggest that m6A aberrant expression plays an important role in cancer.
Fengjie Jiang, Xiaozhu Tang, Chao Tang, Zhen Hua, Mengying Ke, Chen Wang, Jiamin Zhao, Shengyao Gao, Artur Jurczyszyn, Siegfried Janz, Meral Beksac, Fenghuang Zhan, Chunyan Gu, Ye Yang   +13 more
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Review on circular RNAs and new insights into their roles in cancer

Computational and Structural Biotechnology Journal, 2021
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA molecules derived from exonic or intronic sequences by precursor mRNA back-splicing.
Xiaozhu Tang, Hongyan Ren, Mengjie Guo, Jinjun Qian, Ye Yang, Chunyan Gu   +5 more
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BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans

Frontiers in Pharmacology, 2023
Introduction: BuShen HuoXue (BSHX) decoction is commonly used in the clinical treatment of premature ovarian failure because it can increase estradiol level and decrease follicle-stimulating hormone level.
Kanglu Wu, Xudong Zhao, Xian Xiao, Miao Chen, Liang Wu, Chao Jiang, Jing Jin, Lei Li, Qinli Ruan, Jun Guo   +9 more
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Gold(I) selenium N-heterocyclic carbene complexes as potent antibacterial agents against multidrug-resistant gram-negative bacteria via inhibiting thioredoxin reductase

Redox Biology, 2023
Multidrug-resistant (MDR) Gram-negative bacteria have become a global threat to human life and health, and novel antibiotics are urgently needed. The thioredoxin (Trx) system can be used as an antibacterial target to combat MDR bacteria.
Xiuli Chen, Shibo Sun, Sheng Huang, Han Yang, Qing Ye, Lin Lv, Yanshan Liang, Jinjun Shan, Jianqiang Xu, Wukun Liu, Tonghui Ma   +10 more
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Steroid 5α-Reductase Type I Induces Cell Viability and Migration via Nuclear Factor-κB/Vascular Endothelial Growth Factor Signaling Pathway in Colorectal Cancer

Frontiers in Oncology, 2020
Colorectal cancer (CRC) is a common malignant tumor of the digestive system. Steroid 5α-reductase type I (SRD5A1), as an important part of the steroid metabolism, converts testosterone to dihydrotestosterone and regulates sex hormone levels, which ...
Rongfang Wei, Rongfang Wei, Sixia Zhong, Li Qiao, Mengjie Guo, Miaomiao Shao, Suyu Wang, Bin Jiang, Ye Yang, Chunyan Gu, Chunyan Gu   +10 more
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The holistic phase model of early adult crisis [PDF]

, 2013
The objective of the current study was to explore the structural, temporal and experiential manifestations of crisis episodes in early adulthood, using a holistic-systemic theoretical framework.
Gordon R. T. Wright, Robinson, O., Jonathan A. Smith, Wright, Gordon R.T., Smith, Jonathan A., Oliver C. Robinson, Robinson, Oliver C., Wright, Gordon R. T.   +7 more
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Attentional vigilance of food information in disordered eating behaviors

Frontiers in Psychiatry, 2023
IntroductionDisordered eating behaviors (DEBs) are very common among female college students, which seriously endanger their health and well-being. Therefore, the study of the mechanism of DEBs can provide effective evidence for early detection and ...
Luyao Jin, Wenyue Han, Wenyue Han, Zheng Zheng   +3 more
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Targeting RFWD2 as an Effective Strategy to Inhibit Cellular Proliferation and Overcome Drug Resistance to Proteasome Inhibitor in Multiple Myeloma

Frontiers in Cell and Developmental Biology, 2021
The potential to overcome resistance to proteasome inhibitors is greatly related with ubiquitin-proteasome system during multiple myeloma (MM) treatment process.
Mengjie Guo, Mengjie Guo, Pinggang Ding, Zhen Zhu, Lu Fan, Yanyan Zhou, Shu Yang, Ye Yang, Chunyan Gu, Chunyan Gu   +9 more
doaj   +1 more source

A possible mechanism to the antidepressant-like effects of 20 (S)-protopanaxadiol based on its target protein 14-3-3 ζ

Journal of Ginseng Research, 2022
Background: Ginsenosides and their metabolites have antidepressant-like effects, but the underlying mechanisms remain unclear. We previously identified 14-3-3 ζ as one of the target proteins of 20 (S)-protopanaxadiol (PPD), a fully deglycosylated ...
Lin Chen, Ruimei Li, Feiyan Chen, Hantao Zhang, Zhu Zhu, Shuyi Xu, Yao Cheng, Yunan Zhao   +7 more
doaj   +1 more source