Results 91 to 100 of about 48,643 (239)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

THE INTEGRATIVE APPROACH TO THE PSYCHO- PHYSICAL REHABILITATION ISSUES OF BREAST CANCER SURVIVORS

Journal of Cancer Rehabilitation
Background Survival rates for breast cancer are increasing, but many clinical needs in a larger and larger population of survivors are not properly met.
Cristina Accetta, Daniela Belella, Annalisa Di Micco, Alessio Filippone, Cristina Rossi, Maria Maddalena Rossi, Claudia Maggiore, Luana Forcina, Maria Natale, Francesca Veccia, Daniela Pia Rosaria Chieffo, Riccardo Masetti, Stefano Magno   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of an Interdisciplinary Integrative Group-Based Program for Patients with Cancer: Prospective, Nonrandomized Intervention Study with a Waiting-List Control

Current Oncology
Background/Objectives: Cancer is a disease with a rising global incidence each year, and an interdisciplinary approach for both its treatment and care is needed. This study aimed to evaluate the effects of a 10-week interdisciplinary integrative oncology
Burcu Babadağ Savaş, Bettina Märtens, Yvonne Ziert, Diana Steinmann   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modified Sijunzi Decoction Inhibits Pancreatic Cancer Progression and Improves Immune Suppression: Network Pharmacology and Experimental Validation

Drug Design, Development and Therapy
Yuan Zhang,1,2 Linjie Ruan,1,2 Xin Li,1,2 Waimei Si,1,2 Peiwen Yang,1,2 He Ba,1,2 Zhen Chen1,2 1Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; 2Department of Oncology, Shanghai Medical ...
Zhang Y, Ruan L, Li X, Si W, Yang P, Ba H, Chen Z   +6 more
doaj  

Asparagusofficinalis potentially supports cancer care: a systematic review of randomized and non-randomized clinical studies

Frontiers in Nutrition
ObjectiveTo evaluate effectiveness and safety of Asparagus officinalis in cancer care.MethodsPubMed, the Cochrane Library, EMBASE, Web of Science, Scopus and four Chinese databases were searched up to January 9, 2025.
Chen Shen, Xiao-Ti Wu, Xue-Feng Wang, Zhi-Jie Wang, Zi-Yu Tian, Nicola Robinson, Nicola Robinson, Jian-Ping Liu, Jian-Ping Liu   +8 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Complementary therapies in early breast cancer: Oncologists’ evidence-based decisions in a Southeast European vignette survey

Biomolecules & Biomedicine
Complementary therapies are increasingly integrated into the framework of integrative oncology. While numerous complementary therapies provide potential benefits, some may also carry risks, including interactions with conventional cancer treatments. The
Teo Buhovac, Žarko Bajić, Mario Nalbani, Lazar Popović, Milan Risteski, Nikola Milašević, George Dimitrov, Anes Pašić, Marija Karaga, Eduard Vrdoljak   +9 more
doaj   +1 more source