Results 101 to 110 of about 126,581 (349)

Integrating psychotherapy with the hierarchical taxonomy of psychopathology (HiTOP).

Journal of Psychotherapy Integration, 2018
In this paper we present the Hierarchical Taxonomy of Psychopathology (HiTOP), an evidence-based alternative to the categorical approach to diagnostic classification with considerable promise for integrative psychotherapy research and practice. We first review issues associated with the categorical approach that may have constrained advances in ...
Christopher James Hopwood, Michael Bagby, Tara M. Gralnick, Eunyoe Ro, Camilo Ruggero, Stephanie Mullins-Sweatt, Roman Kotov, Bo S. Bach, David C Cicero, Robert Krueger, Christopher Patrick, Michael Chmielewski, Colin G. DeYoung, Anna Docherty, Nicholas R Eaton, Kelsie T. Forbush, Masha Y. Ivanova, Robert D Latzman, Aaron L. Pincus, Douglas B Samuel, mark H. waugh, Aidan G.C. Wright, Johannes Zimmermann   +22 more
openaire   +3 more sources

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Brain rhythms of pain [PDF]

, 2017
Pain is an integrative phenomenon that results from dynamic interactions between sensory and contextual (i.e., cognitive, emotional, and motivational) processes.
Gross, Joachim, Ploner, Markus, Sorg, Christian   +2 more
core   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Integrative taxonomy

, 2020
Species of the genus Urotricha (Ciliophora: Prostomatea) are known to be key planktonic ciliates. Especially during the phytoplankton spring bloom in various freshwater systems, they consume a large proportion of the algal biomass. In lake plankton, around 20 different species of urotrichs occur throughout an annual cycle, and some of them turned out ...
openaire   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

A taxonomy of microservice integration techniques

Information and Software Technology
Context: Microservices have become an important architectural style for building robust and scalable software systems. A system's functionality is split into independent units, the microservices, that communicate over a network and can be deployed independently.
Georg-Daniel Schwarz, Andreas Bauer, Dirk Riehle, Nikolay Harutyunyan   +3 more
openaire   +2 more sources

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Characteristics of microplastics in tributaries of the upper Brahmaputra River along the Himalayan foothills, India

Environmental Research Communications
Microplastic (MP) pollution is a global concern, yet its presence in riverine environments has received limited research attention. This study aimed to evaluate MP levels and identify their potential sources in river surface water and nearby soil samples
Prasun Goswami, Punyasloke Bhadury
doaj   +1 more source

Problem Based Learning and its use on the Automotive Engineering Design Course at Coventry University [PDF]

, 1998
The Automotive Engineering Design course at Coventry University has been in operation since October 1989 and has earned a reputation for creating able engineers well prepared for industry. When originally conceived, a problem led approach to learning was
Robotham, AJ
core   +1 more source