Results 161 to 170 of about 18,494 (260)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Integrative taxonomy reveals previously undescribed diversity within the <i>Gloydius himalayanus</i> complex (Squamata, Viperidae, Crotalinae) from the Himalaya and Hindu Kush. [PDF]

Zookeys
Jablonski D, Tillack F, Mahlow-Tillack K, Petzold A, Wilzo M, Das A, Idrees M, Baniya CB, Masroor R, Hofmann S.   +9 more
europepmc   +1 more source

Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art

Advanced Intelligent Discovery, EarlyView.
Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser, Haseeb Muhammad, Junaid Younas, Gillian Lovell, Bianca Migliori, Andreas Dengel, Sheraz Ahmed   +6 more
wiley   +1 more source

Integrative Taxonomy of Nuchequula longicornis (Teleostei: Leiognathidae) from Chinese Waters: Morphological Analysis, Mitogenomic Characterization, and Phylogenetic Implications. [PDF]

Biology (Basel)
Yang NY, Zeng S, Yang DY, Zhong JS, Liu P, Wang XD, Chen JJ.   +6 more
europepmc   +1 more source

An Autonomous Large Language Model‐Agent Framework for Transparent and Local Time Series Forecasting

Advanced Intelligent Discovery, EarlyView.
Architecture of the proposed large language model (LLM)‐based agent framework for autonomous time series forecasting in thermal power generation systems. The framework operates through a vertical pipeline initiated by natural language queries from users, which are processed by the LLM Agent Core powered by Llama.cpp and a ReAct loop with persistent ...
William Gouvêa Buratto, Gabriel Villarrubia Gonzalez, Ademir Nied, Laio Oriel Seman, Anne Carolina Rodrigues Klaar, Stefano Frizzo Stefenon   +5 more
wiley   +1 more source

Integrative Taxonomy Clarifies the Taxonomic Status of the Morphologically Intermediate Form Between Tropidothorax cruciger and T. sinensis (Hemiptera: Lygaeidae). [PDF]

Insects
Zheng C, Zhu X, Zhang Y, Wang Y, Bu W.
europepmc   +1 more source

Parametric Analysis of Spiking Neurons in 16 nm Fin Field‐Effect Transistor Technology

Advanced Intelligent Discovery, EarlyView.
Energy efficient computing has driven a shift toward brain‐inspired neuromorphic hardware. This study explores the design of three distinct silicon neuron topologies implemented in 16 nm fin field‐Effect transistor technology. While the Axon‐Hillock design achieves gigahertz throughput, its functional fragility persists. The Morris–Lecar model captures
Logan Larsh, Raiyan Siddique, Sarah S. Sharif, Yaser Mike Banad   +3 more
wiley   +1 more source

A revision of the genus <i>Beesia</i> (Ranunculaceae) as informed through integrative taxonomy, with description of a new species from Sichuan (China). [PDF]

Front Plant Sci
Erst AS, Mitrenina EY, Krivenko DA, Erst TV, Cheldysheva YV, Gorbenko IV, Borosova R, Lian L, Ling YY, Peng HW, Zhang J, Baasanmunkh S, Choi HJ, Tatanov IV, Kuznetsov AA, Sharples MT, Xiang KL.   +16 more
europepmc   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Expanding Knowledge of Sea Pen (Octocorallia: Pennatuloidea) Diversity and Distribution Through Integrative Taxonomy: Insights From Hong Kong's Coastal Waters. [PDF]

Ecol Evol
Heung BYW, Li YX, Loke HX, Kei K, Lai VCS, Chan LL, Qiu JW.   +6 more
europepmc   +1 more source