Results 61 to 70 of about 173,723 (292)
Inositol hexakisphosphate is required for Integrator function
Nature Communications, 2022 Integrator is a multi-subunit protein complex with roles in noncoding RNA 3′-end processing and mRNA transcription attenuation. Here, the authors reveal a conserved binding site for IP6 in the Integrator cleavage module and show that IP6 binding is ...
Min-Han Lin +6 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Проблема деиндустриализации в экономике России
Ученые записки Российской академии предпринимательства, 2021 Author analyzes background and consequences of deindustrialization in the USA and the Russian Federation. Analysis ofhistorical background shows that solutions for negative factors of deindustrialization are connected with competent understanding of ...
S. V. Firsov
doaj
Effect of interactions between harvester ants on forager decisions
Frontiers in Ecology and Evolution, 2016 Harvester ant colonies adjust their foraging activity to day-to-day changes in food availability and hour-to-hour changes in environmental conditions.
Jacob D Davidson +6 more
doaj +1 more source
The combination of circle topology and leaky integrator neurons remarkably improves the performance of echo state network on time series prediction. [PDF]
PLoS ONE, 2017 Recently, echo state network (ESN) has attracted a great deal of attention due to its high accuracy and efficient learning performance. Compared with the traditional random structure and classical sigmoid units, simple circle topology and leaky ...
Fangzheng Xue, Qian Li, Xiumin Li
doaj +1 more source
QYMSYM: A GPU-Accelerated Hybrid Symplectic Integrator That Permits Close Encounters
, 2010 We describe a parallel hybrid symplectic integrator for planetary system integration that runs on a graphics processing unit (GPU). The integrator identifies close approaches between particles and switches from symplectic to Hermite algorithms for ...
Alexander Moore +21 more
core +1 more source
Data integration under integrity constraints [PDF]
Information Systems, 2002 Data integration systems provide access to a set of heterogeneous, autonomous data sources through a so-called global schema. There are basically two approaches for designing a data integration system. In the global-as-view approach, one defines the elements of the global schema as views over the sources, whereas in the local-as-view approach, one ...
Andrea Cali +3 more
openaire +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source